| Description | ACTIVE HALF-LIFE: 2 days
CLASSIFICATION: Non-steroidal aromatase inhibitor
DOSAGE: 0.5-1 mg/day
ACNE: No
WATER RETENTION: No
HBR: No
HEPATOTOXICITY: No
AROMATIZATION: No
MANUFACTURER: Nakon Medical
WAREHOUSE: International Warehouse 12
SUBSTANCE: Anastrozole | Active: ANASTROZOLE Tablets
Molar mass: 293.366 g/mol
CAS ID: 120511-73-1
Formula: C17H19N5
Elimination half-life: 46.8 hours
Trade name: Arimidex, others
Metabolism: Liver (85%) | Tablet Count: 50 Pills
Dose: 80 – 120mcg per day
Cycle: 6-8 weeks.
Bioavailability: 89–98% (orally)
Molar mass: 277.19
Elimination half-life: 36–48 hours
Metabolism: Hepatic (negligible) | Active Ingredient: Oxandrolone 10mg
Active Half-life: 9 Hours
Classification: Anabolic Steroid
Dosage Men: 50-100 Mg/day
Dosage Women: 5-30 Mg/day
Acne: Rarely
Water Retention: No
Hbr: No
Hepatoxity: Low
Aromatization: No | Active: (anastrozole) Tabs
Molar mass: 293.366 g/mol
CAS ID: 120511-73-1
Formula: C17H19N5
Elimination half-life: 46.8 hours
Trade name: Arimidex, others
Metabolism: Liver (85%) | ACTIVE INGREDIENT: Exemestane 25 mg
TABLET COUNT: 30 COUNTS
ACTIVE HALF-LIFE: 9 HOURS
CLASSIFICATION: ANABOLIC STEROID
DOSAGE MEN: 25-50 MG/DAY
DOSAGE WOMEN: 5-30 MG/DAY
ACNE: RARELY
WATER RETENTION: NO
HBR: NO
HEPATOXITY: LOW
Ship From: Europe |
| Content | Oxy 50, the active ingredient is Oxymetholone.
The effects of the drug:
Awesome set of muscle mass.
Increased hemoglobin synthesis.
Growth of the power indicators.
Acceleration of protein synthesis.
Eliminating pain in the joints.
Possible side effects:
Hepatotoxicity (negative effect on the liver at moderate doses can be reduced).
High blood pressure (due to heavy water retention).
Diarrhea.
Headaches, nausea, vomiting, stomach pain, apathy, lethargy, lack of appetite.
Progestin activity.
Acne.
Side effects can be avoided in advance by making analyzes and carrying out post-cycle therapy.
Oxy 50 Cycles
Oxy 50 cycle for beginners - 6 weeks of cycle, the first week of receiving Oxy 50 at 50 mg per day, the second week, 100 mg per day until the end of the cycle, but you should know one truth: you will lose 70% of gained weight, but there is a plus, it depends on your body’s response to the drug.
Oxy 50 cycle for experienced users - 10 weeks of taking, the first seven weeks Sustanon 350 at 750 mg per week + Oxy 50 at 150 mg per day, the last three weeks, Dianabol at 30-50 mg per day + Propionat 100 at 400 mg per week, to maintain the obtained results.
Warnings: Keep out of reach of children. For adults only. | Anastrozole 1mg x 100 tablets
Anastrozole is more often used in conjunction with other steroids to lower estrogen in the body. Many anabolic steroids will convert, or aromatize, in the body into estrogen, which causes many of the unwanted side effects like bloating and acne. Arimidex is one of the best compounds to lower the aromatizing effect of steroids. | | | | Exemestane is a synthetic androgen analogue. It’s is a steroidal inhibitor of aromatase which binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.
Exemestane has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.
This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Exemestane decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers. Exemestane is usually not used in women of childbearing age.
Exemestane is usually taken once a day after a meal. Take Exemestane at around the same time every day. You may need to take Exemestane for several years or longer. Continue to take Exemestane even if you feel well. Do not stop taking Exemestane without talking to your doctor.
Effect On Estrogens
Plasma estrogen (estradiol, estrone, and estrone sulfate) suppression is seen starting at a 5-mg daily dose of Exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose. Exemestane 25 mg daily reduces whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in postmenopausal women with breast cancer. After a single dose of Exemestane 25 mg, the maximal suppression of circulating estrogens occurres 2 to 3 days after dosing and persisted for 4 to 5 days.
Effect On Corticosteroids
In multiple-dose trials of doses up to 200 mg daily, Exemestane selectivity was assessed by examining its effect on adrenal steroids. Exemestane did not affect cortisol or aldosterone secretion at baseline or in response to ACTH at any dose. Thus, no glucocorticoid or mineralocorticoid replacement therapy is necessary with Exemestane treatment.
Other Endocrine Effects
Exemestane does not bind significantly to steroidal receptors, except for a slight affinity for the androgen receptor (0.28% relative to dihydrotestosterone). The binding affinity of its 17dihydrometabolite for the androgen receptor, however, is 100 times that of the parent compound.
Daily doses of Exemestane up to 25 mg had no significant effect on circulating levels of androstenedione, dehydroepiandrosterone sulfate, or 17-hydroxyprogesterone, and were associated with small decreases in circulating levels of testosterone.
Increases in testosterone and androstenedione levels have been observed at daily doses of 200 mg or more. A dose-dependent decrease in sex hormone binding globulin (SHBG) has been observed with daily Exemestane doses of 2.5 mg or higher.
Slight, nondose-dependent increases in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels have been observed even at low doses as a consequence of feedback at the pituitary level. Exemestane 25 mg daily had no significant effect on thyroid function [free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH).
Absorption
Exemestane is distributed extensively into tissues. Exemestane is 90% bound to plasma proteins and the fraction bound is independent of the total concentration. Albumin and α11-acid glycoprotein both contribute to the binding. The distribution of Exemestane and its metabolites into blood cells is negligible.
Metabolism
Exemestane is extensively metabolized. The initial steps in the metabolism of Exemestane are oxidation of the methylene group in position 6 and reduction of the 17-keto group with subsequent formation of many secondary metabolites.
Each metabolite accounts only for a limited amount of drug-related material. The metabolites are inactive or inhibit aromatase with decreased potency compared with the parent drug. One metabolite may have androgenic activity [see Pharmacodynamics]. Studies using human liver preparations indicate that cytochrome P 450 3A4 (CYP 3A4) is the principal isoenzyme involved in the oxidation of Exemestane. Exemestane is metabolized also by aldoketoreductases. |
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