|Content||CJC-1295 is a synthetic GHRH (growth hormone releasing hormone) analogue made up of 30 amino acids. It has been found to be highly effective with regards to the increase of growth hormone secretion and IGF-1 without negatively affecting the pulsatility of GH secretion.
CJC-1295 is often combined with Ipamorelin due to its enhanced specificity as a GHRH. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated and perfect when combined with Ipamorelin.
Gland Stimulated: Pituitary
Benefits of CJC-1295:
Increased growth hormone secretion and IGF-1 Levels with no increase in prolactin
Increased Body Weight and Length through increased protein synthesis
Increased Muscle Growth
Increased Bone Density
Improved Immune Function
Improved Cognition and Memory
Increased Collagen Production
Increased Fat Loss
Increased Cellular Repair and Regeneration
CJC-1295 also promotes slow wave deep sleep, which is responsible for the highest level of muscle growth and memory retention and rejuvenation
Two types of CJC 1295:
GHRH (growth hormone releasing hormone) is produced in the hypothalamus. Its pulsatile release from the hypothalamus triggers a pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life = the time required to remove half of the substance from the blood. The shorter the half-life, the more rapidly the substance is removed from the body, and the less its effect on the body).
The first 29 amino acids of GHRH is the active segment. They are available as a manufactured peptide called Sermorelin. Sermorelin was further modified to increase its half-life to 30 minutes. This is called CJC 1295. CJC-1295 was further modified by adding DAC (Drug Affinity Complex) to it. DAC binds to a blood protein called albumin, which increases it's half-life to 8 days. It is called CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form which mimics a more normal physiologic GH spike each night.
The longer half-life from the DAC binding to albumin means injections are only required once or twice per week. However, the long half-life and relatively constant blood level provide a constant stimulus for GH release from the pituitary through the GHRH receptor, which is not physiological. This can decrease the GH pulse amplitude which will result in decreased GH tissue stimulation.
It is recommended when using a long-acting CJC molecule to have 'hormone holidays' of three months each three to six months, to allow the pituitary to 'recover'. During the holidays, Sermorelin is used instead of CJC 1295 + DAC.
The 'hormone holidays' may also minimize the risk of GH resistance developing. This resistance, or insensitivity, may occur via antibodies forming that bind to and inactivate GH, or by a decreased number of GH receptors on tissues (down-regulation). These are theoretical concerns as no long-term studies have been undertaken to clarify the issues.
Side effects of CJC-1295 may include injection site reactions (irritation, erythema, induration, pain, itching), headache, diarrhea, vasodilation (flushing, warmth, transient hypotension), nausea, abdominal pain.||This peptide CJC-1295 CJC-1295 W-DAC 2MG is also an artificial growth hormone. This is one of the best hormone because of its versatility and can be used in muscle build-up, weight gain, weight loss, anti-aging, and increasing in growth hormones. Take this from 0.5mg-2mg per week 20 at anytime of the day. Inject this 20 minutes prior to eating.
||Melanotan II analog of alpha-melanocyte stimulating hormone (a-MSH). Melanotan peptides are safe and efficacious with growing long term data. Melanotan 2 is a freeze dried peptide sealed in a sterile multi-use vial. Tanning injections of synthetic potent a-MSH allow for development of photo-protective suntans in all skin types.
Melanotan 2 Dosage
Range: 100mcg – 1mg
Melanotan II Side Effects
Melanotan injections act on melanocytes to stimulate melanin production. Melanin is the body’s pigment responsible for a photoprotective safe tan.
Sunless tanning injections begin with the peptide sequence: His-Phe-Arg-Trp. Melanotan peptides Melanotan II binds to melanocortin receptors influencing pigmentation, inflammation, energy, appetite and sexual function. Melanotan 2 has a small protective amino acid structure that effects the melanocortin 1, 3, 4 and 5 receptors.
Melanotan 2 Peptide Hormone
Melanotan 2 is a small efficient molecule as compared to the linear original Melanotan I design after natural melanocyte stimulating hormone peptide. Melanotan is approximately 1,000 times more potent than natural a-MSH. Melanotan half life of minutes, Melanotan 2 half life ~1 hour.
Melanin skin tanning after Melanotan injection
Folks who never tan, always burn in the sun, can achieve a natural tan when using Melanotan II. For people with sun allergies/mutated receptors, synthetic melanotropin peptide supplements offer life changing opportunity. A natural tan developed over time is the best defense against cancer, to which the fair skin can now acheive. Melanotan was designed to reduce cancer rates and potentially become effective as a sunless tanning agent.
Fitzpatrick skin type: Skin type I and II, the lower of the skin types on the Fitzpatrick scale are the best candidates for Melanotan.
Athletes and fitness enthusiasts use Melanotan for accelerated tanning, libido increase and appetite suppression. Melanotan 2 was dubbed the Barbie drug and has been highlighted in wired magazine. Synthetic melanocortin therapy helps attain a tan with the least amount of exposure to harmful ultraviolet radiation. Melanotan II continues to be the most effective tanning peptide sold online.
Fitzpatrick Skin Type Description
I Extremely fair skin, always burn, never tans.
II Fair skin, always burns, sometimes tans.
III Medium skin, sometimes burns, always tans.
IV Olive skin, rarely burns, always tans.
V Moderately pigmented brown skin, never burns, always tans.
VI Markedly pigmented black skin, never burns, always tans.
Peptide Hormone Therapy: Melanotan stimulates melanin, particularly low fitzpatrick types.
Disclaimer: Please pursue information regarding the usage of these products from your own research, academic journals, or the research of your in-house scientific team. Products sold for research purposes are not for human consumption. Melanotan Peptides are not known to contain filler (mannitol).
review melanotan results chart melanin density after tanning injections
Reconstituted with bacteriostatic water, Melanotan 2 research peptide remains potent and preserved. Reconstituting Melanotan 2 peptide is a necessity and will require proper due diligence for results. Nasal sprays, pre-mixed Melanotan 2, pills, oral melanotan2 are not legitimate. Enzymes will render the peptide inactive if ingested. Purchase only pure Melanotan II custom synthesis.
Melanotan Shipping: Melanotan peptides are durable and stable. Shipping in the summer not a problem for tanning melanocortins. When receiving MT-2 it is recommended to store in the refrigerator. Save money and do not pay for cold melanotan 2 shipments. Further, do not store Melanotan 2 in freezer.
Mixing Melanotan 2: 1-2ml Bacteriostatic water reconstitutes and preserves tanning peptide Melanotan best. Dilute with more volume for improved dosing accuracy (micrograms).
Dosage Calculator: Add 100 units (1ml) of water to the vial. 1ml Bacteriostatic water will minimize injection volume and simplify arithmetic. Dosing measurements are often mentioned in both milligram (mg) and microgram (mcg).
1ml syringe (U100), 1ml Bac Water to Reconstitute
Calculations for .5mg or 500mcg dose:
Step 1 1ml
Step 2 10mg Melanotan II
Step 3 1ml Bacteriostatic Water
Step 4 500mcg Dose
5 units on your insulin syringe (approximately 1/20th of a U100 syringe).
Needles: 29-31 gauge X 1/2″, 1 CC (100 unit). That is a typical insulin needle used to mix as well as inject. Use needles one time only. Once your technique perfected, injections are almost painless. Smaller 1/2 and 1/3cc syringes offer greater measurement accuracy and pre-loading convenience.
Melanotan Dosage: Your first injection should be a very small dose, for example .25mg (250mcg). See how you react. Goal should be to feel nothing. Dose after dinner, before bed. Any dosing chart stating that you should take a high dose (according to your weight) is dated and potentially dangerous.
Loading dose: Load with .5-1mg once a day. People who have used doses in this range generally report getting excellent results. Don’t worry if you miss occasional days. It will not make much difference, focus on the cumulative effects. A tan generally sets in 3 days after UV rays. Dose and expose yourself gradually to UVR when tanning.
Maintenance dosing: Maintenance is taking doses less frequently than daily to avoid becoming darker than you want. Yes, that will happen. With enough UVR, you will get much darker than you have even been before. A maintenance dose can help prolong super-physiological photo-protection MT-2 delivers.
UV Radiation: Melanotan is a poor sunless tanner. UV (from sun or a tanning bed) light is necessary to develop a tan for most folks. Without it, almost nothing happens. In other words, NO UV = NO TAN. Melanotan use for a full month and with UV exposure, you (and your friends) will be astounded by how fast and how dark MT-II tanning results. Areas of skin that are typically sun-exposed in your day to day life will respond more readily to the effects of the melanotan peptides, take photo therapy serious with Melanotan II.
Melanotan 2 Weight Loss: Melanotan II peptide usage results in adipocyte lipolysis. Dose low-moderate between meals to increase fatty acid oxidation, reduce food intake, and increase energy.
Side-effects of Melanotan II
Possible short-term side effects include: nausea, appetite loss, facial flushing and increased libido. Melanotan side effects may be noticeable during the first few days of treatment but should taper off as the body desensitizes.
Do you have to inject Melanotan Peptides?
Yes. The best, most efficient method of administering Melanotan peptides are subcutaneous (subq) injection. Nasal sprays are inconsistent and inefficient at best. No detectable levels were observed following oral melanotan dosing.
Note: There are many things you will need to consider before experimenting with melanotans peptide. Cyclic analogues (Melanotan II) have a wide range of peripheral effects and systemic control is always going to pose an issue in clinical research. Needless to say, Melanotan2 is not an approved or regulated product. Melanotan is legal to buy, possess, etc.
When supplementing Melanotan to tan keep in mind that tanning is literally a side effect. The tanning response is, in reality, a physiological repair mechanism to UV damage of the cells (epidermis/dermis). Melanocyte stimulating hormone is not going to color your skin, it is going to make your own cells create its own tan and that in turn creates protection. If you are looking to be some bronzed beach God with perfectly uniform and specific color then you are better off to going to mystic tan. Redheads, for example, naturally produce a variant form of melanin that is yellowish-red (pheomelanin). Do not expect a brown tan on ginger skin without serious diligence.
Melanotan Dosage: Knowing your skin type is one detail which will help create a public user log. There are thousands of melanotan users worldwide who share the experience. Raise awareness and help others who want to hear success stories, complications and failures.
Am I a candidate for Melanotan?
Melanotan is best suited for the folks with skin types I & II. Prior sun damage, scars, tattoos, freckles, moles, hair color, etc are deciding factors prospective MT-2 users consider.
How should I dose Melanotan II?
Melanotan II dosage it is recommended to start out small and build up. A typical starting dose is around .25mg and max dose reaching 1mg. Desensitization happens quick, the first administration is an opportunity to dose low to avoid Melanotan 2 side effects. Same goes for bremelanotide (PT-141) dosage unfortunately.
Melanotan Instruction: There is no magic pill or formula. Instructions do not exist for research peptides. Few dermatologists are familiar with Melanotan. The skin is a large, unpredictable organ. Feel comfortable and confident with MT-II before use. Check out as many before and after photos and user logs as you can. A skin type I individual may have to commit months of dedication before dialing in their desired results, be patient and ask questions.
How much Melanotan peptide should I purchase?
Skin Type Dosage
Skin Type I 30-50mg
Skin Type II 20-30mg
Skin Type III 10mg
Should last entire summer or season.
How soon will I see Melanotan results? Change in tone after 2-3 weeks should be anticipated. If you have freckles, expect them to get darker before your actual skin color changes. Brace yourself, within days Melanotan will.
How long will my tan last? A tan developed using Melanotan 2 lasts much longer than an ordinary tan. A well-tanned person returning from a beach holiday will lose most of the tan in a month if they stop getting sun. But if they had been using Melanotan 2 and continued on maintenance after returning, they would still have most of their tan 3 months later.
The information presented on this web site is not intended to take the place of your personal physician’s advice and is not intended to diagnose, treat, cure or prevent any disease.||MGF is an acronym for Mechano Growth Factor. This may be a chemical that many users of conventional drugs do not recognise. This is because it is a replica of a very specific molecular signal and an offshoot of the Insulin-like Growth Factor 1 (IGF-1).
As such, this item is usually only used by more seasoned practitioners looking to boost recovery and subsequent gains in muscle strength, power and mass.
This is because Mechano Growth Factor is a molecular signal used in the body to signal surrounding cells, known as “satellite cells”, to migrate into the muscle and become part of the muscle cell.
This creates a bigger muscle cell and can permanently increase the potential size and force capacity of a given muscle fibre. Therefore it may help improve an athlete’s potential even after a user has stopped including it in their regimen.
So, it is no wonder why many individuals, like aesthetic competitors or sportspeople, seek out the Mechano Growth Factor 2 mg peptide.
However, because of its relative lack of therapeutic uses, compared to other items for those with medical ailments or those who don’t utilise it for the above reasons, it is incredibly difficult to find this item from conventional vendors such as pharmacies or medical facilities.
This means that, if you are looking for these types of agents, you’ll have to buy peptides online, much like many other similar chemicals which are used for related purposes.
However, before getting this, or any other similar item, it is key to understand how this item may be included in a regime in order to get the desired outcomes for which it is acquired. So, below, we look at how this agent is commonly included in regimens, how much of it is used, as well as when, and potential drawbacks to its inclusion in your programme.
Mechano Growth Factor Peptide Doses and Timing
There is a relative scarcity of research looking at what MGF peptide dosage is most ideal for those using it purely to boost size or athletic capability.
However, larger amounts have been reported to produce better outcomes than smaller ones. In terms of a commonly reported amount, the MGF 2mg thrice weekly over a period of four weeks has been used by many of those looking for athletic or structural benefit.
In terms of timing these MGF doses, this agent is usually administered immediately after a workout. The reason for this is due to the relatively short half-life of the chemical, which has a half-life lasting only a few minutes. This means it will be broken down and processed by the body only a few minutes after it has been administered.
So, users choose to administer it directly after a workout where the body is in the process of renewal and repair and anabolic signalling will be strong. But, if administering this item immediately after a workout is not a viable option for some, then the best alternative would be to instead include an esterified form of the agent such as MGF-PEG, which has a polyethylene glycol attachment to extend its half-life to several days.
This can afford a more gradual release and processing of the agent in the body and allows a lot more freedom of when the Mechano Growth Factor can be administered.
The above information should help you select the form of the chemical best suited to your needs and lifestyle, as well as how best to use your form in an attempt to maximize your results from the agent. Now, we can look at the potential adverse events associated with the use of this agent that should be considered when looking at getting it for your regimen.
MGF Peptide Side Effects
Much like the perks behind the use of this agent, research looking at the adverse events associated with the use of this growth factor, or other related new items such as fragment 176-191, particularly for the purposes listed in the above sections, is very thin.
This makes it hard to outline the range of drawbacks that may impact the vast majority of users.
However, from reviewing reports from previous users and suppliers, some MGF peptide side effects can include:
Pain or irritation surrounding the site of administration, as is common with a lot of injectable solutions;
Potential cardiac issues or irregularities.
These should all be considered before you buy MGF peptide to ensure you are on the lookout for any particular issues with use and ensure an enjoyable, effective and efficient period of use.||Insulin-like growth factor-1 (IGF-1) helps encourage normal bone and tissue growth and development and also has the ability to decrease blood glucose levels.
IGF-1 advances to fat cells and therefore burns fat. Subsequently, it increases lean body mass and decreases fat. These effects are desired mostly by athletes and bodybuilders. Increased IGF-1 levels are also comparable to weight gain. This weight gain is a result of lean body mass growth, not fat production.
IGF-1 is favored in the bodybuilding industry and for people who workout regularly. It helps enhance recovery time after workout and improves energy during the workout.
IGF-1 injections are common for adults and children if they have a growth hormone deficiency. IGF-1 contains many necessary amino acids that can help children who are not developing at a standard rate and supplement adults that are deficient.
Research has also shown that the anabolic effects of IGF-1 may reflect inhibited protein breakdown and stimulated protein synthesis in skeletal muscle and that this response may be caused by a direct effect of IGF-1 on muscle tissue, therefore assisting burns on the skin and other tissue abnormalities.
Mechanism of Action
IGF-1 is a hormone found naturally in human blood. Its primary function is to manage the effects of growth hormone in the body. Normal IGF-1 and growth hormone functions include tissue and bone growth. IGF-1 is formed in different tissues as a result of growth hormone in the blood.
IGF-1 promotes systemic body growth, and has growth-stimulating effects on mostly every cell in the body, mainly bone, cartilage, skeletal muscle, liver, kidney, nerve, skin and lung cells. As well as the insulin-like effects, IGF-1 can also manage cellular DNA synthesis.
Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area. IGF-1 can also be administered intramuscularly.
Before administering IGF-1, always be sure to use a clean and sterile syringe.
Hold the IGF-1 vial upright and insert the syringe in the center of the cap.
Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
Before administering the syringe, use alcohol to cleanse the area of skin.
Pinch the skin around the area to be injected, leave about 2 cm on each side.
Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
Depress the plunger fully, until the syringe is empty, and carefully draw out.
Dosage Amount: For lean muscle growth and fat loss
40 mcg - 50 mcg daily (men)
10 mcg - 20 mcg daily (women)
IGF-1 should not be injected more than twice daily
A typical dosage cycle of IGF-1 will continue for 2 to 12 weeks
Children and adults who are prescribed IGF-1 for development deficiency should consult with a care provider about correct dosing.
The side effects of IGF-1 can be similar to those of other growth hormones. These include growth of excess body tissue, also known as acromegaly, and damage to the joints, liver, and heart. IGF-1 could possibly cause joint pain, muscle pain, headaches and nausea. IGF-1 can also decrease levels of blood glucose, resulting in hypoglycemia. Researchers also associate IGF-1 with an increased risk of developing some cancers, such as lung, breast, colorectal and prostate.
Facilitation of protein synthesis in the body
Regulation of stored fat and channeling it to be used for energy production, resulting in fat loss
Promotion of positive effects on metabolism and increasing lean body mass and muscle growth
Protection against autoimmune disease, heart disease and plaque buildup
Aid development in young children and adults deficient in essential amino acids
Improvement in blood sugar regulation
Promotion of optimal health, wellness and fitness in users||PT-141 (Bremelanotide) is a popular peptide, its main purpose is increasing the libido. The main feature of this preparation is the possibility of its use both by men and women. PT-141 is absolutely safe, although it is of synthetic origin. The solution administration may be assigned for men at the erectile dysfunction and for women in case of sexual disorder.
Different studies and researches discovered other properties of the preparation. The peptide PT-141 is able to stimulate the production of melanin causing a strong tanning effect. So the laboratory tests of the peptide constantly expand its application areas.
PT-141 is used both by men and women. The main difference between Bremelanotide and such drugs as Viagra and Cialis is that its active substances affect the libido not only blood vessels.
The effects of the use of PT-141
Improvement of sexual potency
Increased sexual drive
Increased coitus duration
Please carefully read the instructions to the PT-141 in order to achieve the desired result at the right time.
Application and dosage of PT-141
To achieve first results it is enough to administrate 0.3 milligrams of the preparation subcutaneously. It is the initial dose allowing to define the effect of the active components on the organism. Further the dosage can be increased if necessary. The optimal dosage for one administration is between 0.5 and 1.5 milligrams.
The first signs of the effectiveness of Bremelanotide appear in a couple of hours after administration. The maximum effect is reached after 3-4 hours. Totally the active substance's effect lasts for 8-10 hours.
Side effects and contraindications
As a part of the study it was found that Bremelanotide has all the features stated in the instructions and perfectly performs its purpose. At the same time some test persons had an increase of blood pressure so the study of the preparation was stopped. Reviews of PT-141 also show that overdosing could negatively affect the level of blood pressure and cause hypertension. Also it should be noted about the possibility of local reactions such as redness of the place of injection. This symptom usually disappears in few minutes and is not considered as complication.|