Exemestane 25mg – Hilma Biocare

$90.00

Availability: In Stock

ACTIVE INGREDIENT: Exemestane 25 mg
TABLET COUNT: 30 COUNTS
ACTIVE HALF-LIFE: 9 HOURS
CLASSIFICATION: ANABOLIC STEROID
DOSAGE MEN: 25-50 MG/DAY
DOSAGE WOMEN: 5-30 MG/DAY
ACNE: RARELY
WATER RETENTION: NO
HBR: NO
HEPATOXITY: LOW
Ship From: Europe

SKU: 101AAS-HB-0-138 Categories: , , ,

Description

Exemestane is a synthetic androgen analogue. It’s is a steroidal inhibitor of aromatase which  binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.

Exemestane has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.

This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Exemestane decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers. Exemestane is usually not used in women of childbearing age.

Exemestane is usually taken once a day after a meal. Take Exemestane at around the same time every day. You may need to take Exemestane for several years or longer. Continue to take Exemestane even if you feel well. Do not stop taking Exemestane without talking to your doctor.

Effect On Estrogens

Plasma estrogen (estradiol, estrone, and estrone sulfate) suppression is seen starting at a 5-mg daily dose of Exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose. Exemestane 25 mg daily reduces whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in postmenopausal women with breast cancer. After a single dose of Exemestane 25 mg, the maximal suppression of circulating estrogens occurres 2 to 3 days after dosing and persisted for 4 to 5 days.

Effect On Corticosteroids

In multiple-dose trials of doses up to 200 mg daily, Exemestane selectivity was assessed by examining its effect on adrenal steroids. Exemestane did not affect cortisol or aldosterone secretion at baseline or in response to ACTH at any dose. Thus, no glucocorticoid or mineralocorticoid replacement therapy is necessary with Exemestane treatment.

Other Endocrine Effects

Exemestane does not bind significantly to steroidal receptors, except for a slight affinity for the androgen receptor (0.28% relative to dihydrotestosterone). The binding affinity of its 17dihydrometabolite for the androgen receptor, however, is 100 times that of the parent compound.

Daily doses of Exemestane up to 25 mg had no significant effect on circulating levels of androstenedione, dehydroepiandrosterone sulfate, or 17-hydroxyprogesterone, and were associated with small decreases in circulating levels of testosterone.

Increases in testosterone and androstenedione levels have been observed at daily doses of 200 mg or more. A dose-dependent decrease in sex hormone binding globulin (SHBG) has been observed with daily Exemestane doses of 2.5 mg or higher.

Slight, nondose-dependent increases in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels have been observed even at low doses as a consequence of feedback at the pituitary level. Exemestane 25 mg daily had no significant effect on thyroid function [free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH).

Absorption

Exemestane is distributed extensively into tissues. Exemestane is 90% bound to plasma proteins and the fraction bound is independent of the total concentration. Albumin and α11-acid glycoprotein both contribute to the binding. The distribution of Exemestane and its metabolites into blood cells is negligible.

Metabolism

Exemestane is extensively metabolized. The initial steps in the metabolism of Exemestane are oxidation of the methylene group in position 6 and reduction of the 17-keto group with subsequent formation of many secondary metabolites.

Each metabolite accounts only for a limited amount of drug-related material. The metabolites are inactive or inhibit aromatase with decreased potency compared with the parent drug. One metabolite may have androgenic activity [see Pharmacodynamics]. Studies using human liver preparations indicate that cytochrome P 450 3A4 (CYP 3A4) is the principal isoenzyme involved in the oxidation of Exemestane. Exemestane is metabolized also by aldoketoreductases.

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DescriptionACTIVE INGREDIENT: Exemestane 25 mg TABLET COUNT: 30 COUNTS ACTIVE HALF-LIFE: 9 HOURS CLASSIFICATION: ANABOLIC STEROID DOSAGE MEN: 25-50 MG/DAY DOSAGE WOMEN: 5-30 MG/DAY ACNE: RARELY WATER RETENTION: NO HBR: NO HEPATOXITY: LOW Ship From: EuropeActive Ingredient: Oxandrolone 10mg Active Half-life: 9 Hours Classification: Anabolic Steroid Dosage Men: 50-100 Mg/day Dosage Women: 5-30 Mg/day Acne: Rarely Water Retention: No Hbr: No Hepatoxity: Low Aromatization: NoActive Ingredient: Stanozolol 10mg Tablet Count: 100 tabs Active Half-life: 9 Hours Classification: Anabolic Steroid Dosage Men: 20-50 Mg/day Acne: Yes Water Retention: No Hbr: perhaps Hepatoxicity: yes Aromatization: No Ship From: USAProduct Name: Halotestin 10mg Active Ingredient: Fluoxymesterone 10mg Active Life: 9 Hours Drug Class: Androgen; Anabolic Steroid Detection Time: 11 Months Common Doses: 10-20 mg/day Blood pressure: Perhaps Acne: Yes Water retention: No Aromatisation: No Liver toxicity: High Decrease HPTA function: NoneActive Ingredient: Clomiphene Citrate (Clomid) Tablet Count: 50 Tab Molar Mass: 405.966 G/mol Formula: C26h28clno Trade Name: Clomid Concentration: 50 mg/cap Presentation: 50 Tablets (Total box 2500mg) Ship From: EuropeACTIVE INGREDIENT: LETROZOLE 5mg TABLET COUNT: 100 COUNTS ACTIVE HALF-LIFE: 9 HOURS CLASSIFICATION: ANTI ESTROGEN DOSAGE: 5mg ACNE: NONE WATER RETENTION: NO HBR: NO HEPATOXITY: LOW AROMATIZATION: NO
ContentExemestane is a synthetic androgen analogue. It’s is a steroidal inhibitor of aromatase which  binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. Exemestane has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Exemestane decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers. Exemestane is usually not used in women of childbearing age. Exemestane is usually taken once a day after a meal. Take Exemestane at around the same time every day. You may need to take Exemestane for several years or longer. Continue to take Exemestane even if you feel well. Do not stop taking Exemestane without talking to your doctor. Effect On Estrogens Plasma estrogen (estradiol, estrone, and estrone sulfate) suppression is seen starting at a 5-mg daily dose of Exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose. Exemestane 25 mg daily reduces whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in postmenopausal women with breast cancer. After a single dose of Exemestane 25 mg, the maximal suppression of circulating estrogens occurres 2 to 3 days after dosing and persisted for 4 to 5 days. Effect On Corticosteroids In multiple-dose trials of doses up to 200 mg daily, Exemestane selectivity was assessed by examining its effect on adrenal steroids. Exemestane did not affect cortisol or aldosterone secretion at baseline or in response to ACTH at any dose. Thus, no glucocorticoid or mineralocorticoid replacement therapy is necessary with Exemestane treatment. Other Endocrine Effects Exemestane does not bind significantly to steroidal receptors, except for a slight affinity for the androgen receptor (0.28% relative to dihydrotestosterone). The binding affinity of its 17dihydrometabolite for the androgen receptor, however, is 100 times that of the parent compound. Daily doses of Exemestane up to 25 mg had no significant effect on circulating levels of androstenedione, dehydroepiandrosterone sulfate, or 17-hydroxyprogesterone, and were associated with small decreases in circulating levels of testosterone. Increases in testosterone and androstenedione levels have been observed at daily doses of 200 mg or more. A dose-dependent decrease in sex hormone binding globulin (SHBG) has been observed with daily Exemestane doses of 2.5 mg or higher. Slight, nondose-dependent increases in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels have been observed even at low doses as a consequence of feedback at the pituitary level. Exemestane 25 mg daily had no significant effect on thyroid function [free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH). Absorption Exemestane is distributed extensively into tissues. Exemestane is 90% bound to plasma proteins and the fraction bound is independent of the total concentration. Albumin and α11-acid glycoprotein both contribute to the binding. The distribution of Exemestane and its metabolites into blood cells is negligible. Metabolism Exemestane is extensively metabolized. The initial steps in the metabolism of Exemestane are oxidation of the methylene group in position 6 and reduction of the 17-keto group with subsequent formation of many secondary metabolites. Each metabolite accounts only for a limited amount of drug-related material. The metabolites are inactive or inhibit aromatase with decreased potency compared with the parent drug. One metabolite may have androgenic activity [see Pharmacodynamics]. Studies using human liver preparations indicate that cytochrome P 450 3A4 (CYP 3A4) is the principal isoenzyme involved in the oxidation of Exemestane. Exemestane is metabolized also by aldoketoreductases.Stanozolol 10mg x 100 tablets Stanzolol is a derivative of dihydrotestosterone, although its activity is much milder than this androgen in nature. It is technically classified as an anabolic steroid, shown to exhibit a slightly greater tendency for muscle growth than androgenic activity in early studies.Fluoxymesterone 10mg x 100 tablets Fluoxymesterone has established itself as a high-quality drug with a high androgenic index. Fluoxy mesteronegives a great increase in strength. Suitable for preparation for competitions, when an athlete needs strength without a large set of muscle mass. In this case, the musculature gets the necessary hardness.[vc_row][vc_column][vc_column_text]
Clomiphene – Post Cycle Therapy The basic need in bodybuilding is the right amount of testosterone secretion of an athlete. It enables them to perform and also gaining the ripped structure. Preference for the testosterone is on top. The testosterone level can be maintained by a right regimen and also with the help of some steroids. One of them is Clomiphene, which can also be quoted as recoveree for testosterone. If the level of testosterone is not up to the mark or the bodybuilder need more push, then it should be used. What is Clomiphene? Clomid is extensively used for the enhancement of testosterone production. It takes a vital place after anabolic steroid cycles. It is the next step after taking anabolic steroids. It works by taking the space of binding sites of estrogen receptors without activating. If the estrogen levels will be low then there is a supposition for hypothalamus. Hypothalamus is gland beneath the brain which secretes hormones. Generally, Clomiphene dosage is at 50mg/day. It has a long life. The body contains the Clomipheneof past dosage, simultaneously keeping the present dose of any bodybuilder. It takes time to get going. For example, if you are taking Clomiphene from last week, and today you have taken the dose, your body also has that amount of past Clomiphenein the system. It’s fine if the blood level is right. Benefits
  • In bodybuilding, it enables those athletes who are already on anabolic steroids but want to reduce their side effects especially that of steroids action changing to increase female sex hormone. One of the examples of this is the excessive size of chest or man boobs (gyno).
  • It also stimulates the testosterone level after completing the course of anabolic steroids.
  • The popularity of clomiphene is due to the resisting factor which enables the bodybuilder to avoid loss of strength and muscle mass. It also improves the appearance of bodybuilders. This is done, due to its binding nature of brain receptors which are solely taken care of male hormonal level. If the male hormones are timely kept in check and the need is fulfilled timely.
Excessive dosage after the first day, if taken more than 50 mg is not recommended. It may cause serious side effects, rather than giving much advantage. Clomiphene is popularly known as Clomid, as it is the brand name. Clomid is generally available in almost all pharmaceuticals. Moreover, it is also available for research purposes mostly in liquid form. The dosage of Clomid is not preferable with any other drug. But, combining with Nolvadex can give maximum results and half of the dose can perform the work of full dosage. As using excessive or full dosage increase the risk of side effects rather than enhancing much. The usage for bodybuilding is quite extensive, as any of the legitimate trainers will give preference to testosterone level. Testosterone level plays a very important role in bodybuilding.
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Letrozole 5mg x 100 tablets Letrozole is a third generation Aromatase Inhibitor (AI) that works by attaching to -and eliminating the aromatase enzyme resposible for producing estrogen. This makes it a perfect choice to combat gynocomastia which it will completely prevent. Letrozole also quite raises LH levels which deems it suitable for post-cycle use. The human body does need estrogen to maintain proper immune function and balance cholesterol ratios in the blood. Since letrozole is so strong at eliminating estrogen, it is not suited for long term use.
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