Exemestanex

$124.20

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ACTIVE HALF-LIFE 9 Hours
TABLET COUNT: 50 COUNTS
 CLASSIFICATION Steroidal aromatase inhibitor
 DOSAGE 12.5-25 mg/day
 ACNE No
 WATER RETENTION No
 HBR No
 HEPATOTOXICITY No
 AROMATIZATION No

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SKU: EURO33787 Categories: , , ,

Description

Exemestanex is a recently developed and potent anti-estrogen medication that works by preventing the conversion of other molecules in the body to estrogen. It is used in a clinical setting in the treatment of post-menopausal breast cancer patients after other treatments have failed. As estrogen is produced in various locations around the body after a woman has gone into menopause (rather than from the ovaries in a premenopause woman), Exemestanex acts on those enzymes. Due to the fact that many steroids are converted into estrogen in the body’s tissue, Exemestanex has proven popular in the bodybuilding community.

Exemestanex Uses

Many anabolic and androgenic steroids are converted into estrogen in the body and, for men, this results in undesirable side effects such as gynecomastia, fat buildup, and water retention (which can hide muscles under a layer of definition-softening water). Exemestanex may even help some to lose body fat, boost testosterone levels (up to 60%) and increase somatomedin (which is anabolic in and of itself). Despite its testosterone boosting properties Exemestanex is not generally used in post-cycle regimes and is at its best on a full cycle.

In the bodybuilding community the recommended intake to avoid estrogen buildup is 12.5 mg to 25 mg a day. Exemestanex is one of the most potent anti-estrogen drugs on the market with studies reporting estrogen levels being lowered as much as 85% in a group of women. Thus, dosages can vary widely depending on personal chemistry and the potency and amount of steroids being taken with as little as 2.5 mg of the drug having a measurable effect in some individuals. 12.5 mg every other day may prove effective for some individuals. Finding out what dosage is appropriate per each individual is important, especially with such a potent anti-estrogen, as too little estrogen in one’s system can actually reduce muscle gains and diminish the sex drive.

Exemestanex Side Effects

Exemestanex can, in men, can increase the risk of cardiovascular disease occurring. Men who are concerned with their cardiovascular health should consider other anti-estrogen medications. Women using Exemestanex for medical reasons may experience a host of side effects from hot flashes and upset stomachs to a number of bone related issues, high blood pressure, and birth defects in pregnant women. As a steroidal suicide aromatase inhibitor, some of Exemestanex’s estrogen lowering effects can be long lasting as it binds irreversibly to estrogen converting enzymes.

Exemestanex generally comes in tablet form with about 25 mg of the drug present and is widely available in most pharmacies both in the US and abroad under that name.

Warnings: Keep out of reach of children. For adults only.

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DescriptionACTIVE HALF-LIFE 9 Hours TABLET COUNT: 50 COUNTS  CLASSIFICATION Steroidal aromatase inhibitor  DOSAGE 12.5-25 mg/day  ACNE No  WATER RETENTION No  HBR No  HEPATOTOXICITY No  AROMATIZATION NoACTIVE INGREDIENT: OXYMETHOLONE 50mg TABLET COUNT: 100 COUNTS ACTIVE HALF-LIFE: 9 HOURS CLASSIFICATION: ANABOLIC STEROID DOSAGE MEN: 50-100 MG/DAY DOSAGE WOMEN: 5-30 MG/DAY ACNE: RARELY WATER RETENTION: NO HBR: NO HEPATOXITY: LOW AROMATIZATION: NO Ship From: EuropeActive Ingredient: Mesterolone 10mg Bottle Count: 50 Tablets Active Half-life: 12 Hours Classification: Anabolic Steroid Dosage Men: 30-100 mg/day Acne: Yes Water Retention: No Concentration: 10 mg/Pill Presentation: 50 Tablets (Total box 500 mg) Dosage: 30-100mg per day over the course of 8-12 weeksACTIVE INGREDIENT: Exemestane 25 mg TABLET COUNT: 30 COUNTS ACTIVE HALF-LIFE: 9 HOURS CLASSIFICATION: ANABOLIC STEROID DOSAGE MEN: 25-50 MG/DAY DOSAGE WOMEN: 5-30 MG/DAY ACNE: RARELY WATER RETENTION: NO HBR: NO HEPATOXITY: LOW Ship From: EuropeActive Ingredient: Stanozolol 10mg Tablet Count: 100 tabs Active Half-life: 9 Hours Classification: Anabolic Steroid Dosage Men: 20-50 Mg/day Acne: Yes Water Retention: No Hbr: perhaps Hepatoxicity: yes Aromatization: No Ship From: USAActive Ingredient: Oxandrolone 10mg Active Half-life: 9 Hours Classification: Anabolic Steroid Dosage Men: 50-100 Mg/day Dosage Women: 5-30 Mg/day Acne: Rarely Water Retention: No Hbr: No Hepatoxity: Low Aromatization: No
ContentExemestanex is a recently developed and potent anti-estrogen medication that works by preventing the conversion of other molecules in the body to estrogen. It is used in a clinical setting in the treatment of post-menopausal breast cancer patients after other treatments have failed. As estrogen is produced in various locations around the body after a woman has gone into menopause (rather than from the ovaries in a premenopause woman), Exemestanex acts on those enzymes. Due to the fact that many steroids are converted into estrogen in the body’s tissue, Exemestanex has proven popular in the bodybuilding community. Exemestanex Uses Many anabolic and androgenic steroids are converted into estrogen in the body and, for men, this results in undesirable side effects such as gynecomastia, fat buildup, and water retention (which can hide muscles under a layer of definition-softening water). Exemestanex may even help some to lose body fat, boost testosterone levels (up to 60%) and increase somatomedin (which is anabolic in and of itself). Despite its testosterone boosting properties Exemestanex is not generally used in post-cycle regimes and is at its best on a full cycle. In the bodybuilding community the recommended intake to avoid estrogen buildup is 12.5 mg to 25 mg a day. Exemestanex is one of the most potent anti-estrogen drugs on the market with studies reporting estrogen levels being lowered as much as 85% in a group of women. Thus, dosages can vary widely depending on personal chemistry and the potency and amount of steroids being taken with as little as 2.5 mg of the drug having a measurable effect in some individuals. 12.5 mg every other day may prove effective for some individuals. Finding out what dosage is appropriate per each individual is important, especially with such a potent anti-estrogen, as too little estrogen in one’s system can actually reduce muscle gains and diminish the sex drive. Exemestanex Side Effects Exemestanex can, in men, can increase the risk of cardiovascular disease occurring. Men who are concerned with their cardiovascular health should consider other anti-estrogen medications. Women using Exemestanex for medical reasons may experience a host of side effects from hot flashes and upset stomachs to a number of bone related issues, high blood pressure, and birth defects in pregnant women. As a steroidal suicide aromatase inhibitor, some of Exemestanex’s estrogen lowering effects can be long lasting as it binds irreversibly to estrogen converting enzymes. Exemestanex generally comes in tablet form with about 25 mg of the drug present and is widely available in most pharmacies both in the US and abroad under that name. Warnings: Keep out of reach of children. For adults only.Oxymetholone 50mg x 100 tablets Oxymetholone is a powerful steroid that produces very noticeable weight gains in a very short time. Unfortunately, it is also highly toxic in the liver and produces some very unfavorable side effects, such as headaches, and bloating. The gains are very dramatic.Exemestane is a synthetic androgen analogue. It’s is a steroidal inhibitor of aromatase which  binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. Exemestane has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Exemestane decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers. Exemestane is usually not used in women of childbearing age. Exemestane is usually taken once a day after a meal. Take Exemestane at around the same time every day. You may need to take Exemestane for several years or longer. Continue to take Exemestane even if you feel well. Do not stop taking Exemestane without talking to your doctor. Effect On Estrogens Plasma estrogen (estradiol, estrone, and estrone sulfate) suppression is seen starting at a 5-mg daily dose of Exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose. Exemestane 25 mg daily reduces whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in postmenopausal women with breast cancer. After a single dose of Exemestane 25 mg, the maximal suppression of circulating estrogens occurres 2 to 3 days after dosing and persisted for 4 to 5 days. Effect On Corticosteroids In multiple-dose trials of doses up to 200 mg daily, Exemestane selectivity was assessed by examining its effect on adrenal steroids. Exemestane did not affect cortisol or aldosterone secretion at baseline or in response to ACTH at any dose. Thus, no glucocorticoid or mineralocorticoid replacement therapy is necessary with Exemestane treatment. Other Endocrine Effects Exemestane does not bind significantly to steroidal receptors, except for a slight affinity for the androgen receptor (0.28% relative to dihydrotestosterone). The binding affinity of its 17dihydrometabolite for the androgen receptor, however, is 100 times that of the parent compound. Daily doses of Exemestane up to 25 mg had no significant effect on circulating levels of androstenedione, dehydroepiandrosterone sulfate, or 17-hydroxyprogesterone, and were associated with small decreases in circulating levels of testosterone. Increases in testosterone and androstenedione levels have been observed at daily doses of 200 mg or more. A dose-dependent decrease in sex hormone binding globulin (SHBG) has been observed with daily Exemestane doses of 2.5 mg or higher. Slight, nondose-dependent increases in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels have been observed even at low doses as a consequence of feedback at the pituitary level. Exemestane 25 mg daily had no significant effect on thyroid function [free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH). Absorption Exemestane is distributed extensively into tissues. Exemestane is 90% bound to plasma proteins and the fraction bound is independent of the total concentration. Albumin and α11-acid glycoprotein both contribute to the binding. The distribution of Exemestane and its metabolites into blood cells is negligible. Metabolism Exemestane is extensively metabolized. The initial steps in the metabolism of Exemestane are oxidation of the methylene group in position 6 and reduction of the 17-keto group with subsequent formation of many secondary metabolites. Each metabolite accounts only for a limited amount of drug-related material. The metabolites are inactive or inhibit aromatase with decreased potency compared with the parent drug. One metabolite may have androgenic activity [see Pharmacodynamics]. Studies using human liver preparations indicate that cytochrome P 450 3A4 (CYP 3A4) is the principal isoenzyme involved in the oxidation of Exemestane. Exemestane is metabolized also by aldoketoreductases.Stanozolol 10mg x 100 tablets Stanzolol is a derivative of dihydrotestosterone, although its activity is much milder than this androgen in nature. It is technically classified as an anabolic steroid, shown to exhibit a slightly greater tendency for muscle growth than androgenic activity in early studies.
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