| Content | Hexarelin, also known as Examorelin and Hexarelin Acetate, is a potent, synthetic hexapeptide and a highly selective agonist (initiates a physiological response when combined with a receptor) of the ghrelin/growth hormone secretagogue receptor and a growth hormone secretagogue.
Usage
Hexarelin is used to stimulate natural growth hormone production, promoting lean muscle growth, rapid fat loss, increased tendon and ligament strength, enhanced flexibility, and better recovery from injuries and training sessions.
By increasing natural growth hormone levels, Hexarelin also enhances production of Insulin-like Growth Factor 1 (IGF-1) in the body. This further drives the growth of lean muscle tissue, improving strength and body composition. Likewise, Hexarelin promotes significant gains in athletic performance, preventing musculoskeletal injury while reducing recovery time between training sessions. In addition, its method of action prevents many of the negative side effects of synthetic hGH administration, including the shutdown of natural growth hormone production
Mechanism of Action
Growth hormone is made and released by the pituitary gland. Hexarelin functions to enhance the natural growth hormone production by amplifying the natural growth hormone releasing signal. This results in a greater secretion of growth hormone from the pituitary gland. Hexarelin then suppresses a hormone in the body called somatostatin, also known as growth hormone inhibiting hormone. Somatostatin causes the body to reduce its natural growth hormone output. By limiting the action of somatostatin, growth hormone production is escalated, resulting in significantly increased natural growth hormone levels.
Hexarelin can bind to and activate the growth hormone secretagogue receptor in the brain similar to its natural counterpart ghrelin. Hexarelin has been studied to be much more potent and stable than gherlin.
The outlying distribution of growth hormone secretagogue in the heart and blood vessels suggests that Hexarelin may have direct cardiovascular actions beyond growth hormone release and neuroendocrine effects.
Administration
Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area. Hexarelin can also be taken orally.
Before administering Hexarelin, always be sure to use a clean and sterile syringe.
Hold the Hexarelin vial upright and insert the syringe in the center of the cap.
Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
Before administering the syringe, use alcohol to cleanse the area of skin.
Pinch the skin around the area to be injected, leave about 2 cm on each side.
Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
Depress the plunger fully, until the syringe is empty, and carefully draw out.
Dosage
Dosage Amount: 200mcg - 300mcg daily, administering 100mcg at a time
Hexarelin is generally administered 2-3 times daily at dosages of 100mcg per administration. As Hexarelin is best suited for athletic performance enhancement rather than anti-aging purposes, it is commonly administered at least 2 times per day to increase growth hormone as much as possible in the limited duration of a cycle (up to 16 weeks). These dosages provide a substantial increase in growth hormone output to facilitate muscle growth, strength gain, fat loss, and recovery from training and injury. For best results, it is recommended to avoid eating one hour before and after administering Hexarelin.
Side Effects
Common side effects of Hexarelin can include feelings of tiredness or lethargy, as growth hormone can increase the desire for sleep as well as its quality and restorative capabilities. Although Hexarelin is a growth hormone releasing peptide, it does not stimulate an increase in appetite through increased ghrelin activity.
Excess dosages may lead to water retention as well as tingling or numbness in the hands and feet. This can be a sign that the dosage is too high and should be reduced. Hexarelin may have a stimulatory effect on adrenocorticotropic hormone (ACTH), cortisol, and prolactin. Though not an issue for the vast majority of users, this may cause interactions with certain medications or unwanted effects in individuals with certain health conditions.
Benefits
Increase growth of lean muscle
Acceleration of weight loss/ fat loss
Increase of tendon and ligament strength
Enhancement of flexibility and joint health
Promotion of quicker recovery from injuries and training
Resistance to musculoskeletal injury
Improvement of sleep quality
Enhancement of athletic performance and physical capacity | | Oxytocin is a hormone secreted by the posterior lobe of the pituitary gland, a pea-sized structure at the base of the brain.
It's sometimes known as the "cuddle hormone" or the "love hormone," because it is released when people snuggle up or bond socially. Even playing with your dog can cause an oxytocin surge, according to a 2009 study published in the journal Hormones and Behavior. But these monikers may be misleading.
Oxytocin can also intensify memories of bonding gone bad, such as in cases where men have poor relationships with their mothers. It can also make people less accepting of people they see as outsiders. In other words, whether oxytocin makes you feel cuddly or suspicious of others depends on the environment.
Oxytocin in women
Oxytocin is a particularly important hormone for women. "Oxytocin is a peptide produced in the brain that was first recognized for its role in the birth process, and also in nursing," said Larry Young, a behavioral neuroscientist at Emory University in Atlanta, Georgia.
The hormone causes uterine contractions during labor and helps shrink the uterus after delivery. When an infant suckles at his or her mother's breast, the stimulation causes a release of oxytocin, which, in turn, orders the body to "let down" milk for the baby to drink.
Oxytocin also promotes mother-child bonding. Studies show that "female rats find pups to be aversive if [the females are] virgins," Young told Live Science. "But once they give birth, the brain is transformed, so they find the pups irresistible," he said. And similar findings are seen in humans.
A 2007 study published in the journal Psychological Science found that the higher a mom's oxytocin levels in the first trimester of pregnancy, the more likely she was to engage in bonding behaviors such as singing to or bathing her baby. [11 Interesting Effects of Oxytocin]
Although maternal bonding may not always be hardwired — after all, human females can adopt babies and take care of them — oxytocin released during pregnancy "does seem to have a role in motivation and feelings of connectedness to a baby," Young said. Studies also show that interacting with a baby causes the infant's own oxytocin levels to increase, he added.
Oxytocin in men
In men, as in women, oxytocin facilitates bonding. Dads who got a boost of oxytocin via a nasal spray played more closely with their 5-month-old babies than dads who didn't get the hormone zap, a 2012 study found. (There is another hormone, called vasopressin, which plays a stronger role in men.)
This anti-social effect of a social hormone brings some nuance to the story of oxytocin. In one study, researchers found that Dutch students given a snort of the hormone became more positive about fictional Dutch characters, but were more negative about characters with Arab or German names. The finding suggests that oxytocin's social bonding effects are targeted at whomever a person perceives as part of their in-group, the researchers reported in January 2011 in the journal PNAS.
In another study, published in PNAS in 2010, men were given a dose of oxytocin and asked to write about their mothers. Those with secure relationships described their moms as more caring after the hormone dose. Those with troubled relationships actually saw their mothers as less caring. The hormone may help with the formation of social memories, according to the study researchers, so a whiff strengthens previous associations, whether good or bad.
"My view of what oxytocin is doing in the brain is making social information more salient," Young said. "It connects brain areas involved in processing social information — whether it's sights, faces, sounds or smells — and helps link those areas to the brain's reward system."
Oxytocin sprays and side effects
Oxytocin nose sprays also have been considered for use in treating autism. The neurological disorder is marked by struggles with social functioning, so a small 2013 study published in the journal PNAS gave a dose to children and teens with autism and asked the participants to identify emotions based on pictures of people's eyes.
The participants weren't any better at identifying the emotions after the oxytocin burst, but the regions of their brains associated with social interaction became more active. The increased processing could mean that a burst of oxytocin might help cement behavioral therapy for kids with the disorder.
"When you think about using oxytocin to treat diseases like autism, you want to make sure you do it in a context where the social information is positive," Young said.
Use of oxytocin sprays outside of a medical context is far murkier, however. The sprays sold online without a prescription promise stress relief and social ease, but they are not regulated by the Food and Drug Administration (FDA). That means that nothing is known about their efficacy, side effects, or even whether they contain any oxytocin.
There are no long-term studies on the side effects of the legitimate oxytocin sprays used in hormone research; most studies give people one dose of the hormone only. Pitocin, a synthetic version of oxytocin given intravenously to stimulate labor, has side effects that include nausea, vomiting and stomach pain. | Tesamorelin (Tesamorelin) is made with growth hormone-releasing factor (GRF).
Tesamorelin is used to reduce excess fat around the stomach that is caused by taking certain HIV medications. This condition is also called lipodystrophy (LYE-poe-DIS-troe-fee).
Tesamorelin is not a weight-loss medication and should not be used to treat obesity.
Tesamorelin (Tesamorelin for injection) is indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy.
Limitations of Use:
Since the long-term cardiovascular safety and potential long-term cardiovascular benefit of Tesamorelin treatment have not been studied and are not known, careful consideration should be given whether to continue Tesamorelin treatment in patients who do not show a clear efficacy response as judged by the degree of reduction in visceral adipose tissue measured by waist circumference or CT scan.
Tesamorelin is not indicated for weight loss management (weight neutral effect).
There are no data to support improved compliance with anti-retroviral therapies in HIV-positive patients taking Tesamorelin.
General Dosing Information
The recommended dose of Tesamorelin is 2 mg injected subcutaneously once a day.
The recommended injection site is the abdomen. Injection sites should be rotated to different areas of the abdomen. Do not inject into scar tissue, bruises or the navel.
Reconstitution Procedure
Tesamorelin must be reconstituted with the diluent provided with the product.
Reconstitute the 2 mg vial of Tesamorelin with 2.1 mL of diluent. Mix by rolling the vial gently in your hands for 30 seconds. Do not shake.
Detailed instructions for reconstituting Tesamorelin are provided in the INSTRUCTIONS FOR USE leaflet enclosed in the boxes containing Tesamorelin and diluent.
Administer Tesamorelin immediately following reconstitution and throw away any unused Tesamorelin solution. If not used immediately, the reconstituted Tesamorelin solution should be discarded. Do not freeze or refrigerate the reconstituted Tesamorelin solution.
Administration
Reconstituted Tesamorelin solution should always be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Tesamorelin must be injected only if the solution is clear, colorless and without particulate matter.
Tesamorelin should be injected subcutaneously into the skin on the abdomen. Injection sites should be rotated to different areas of the abdomen. Do not inject into scar tissue, bruises or the navel. | Insulin-like growth factor-1 (IGF-1) helps encourage normal bone and tissue growth and development and also has the ability to decrease blood glucose levels.
IGF-1 advances to fat cells and therefore burns fat. Subsequently, it increases lean body mass and decreases fat. These effects are desired mostly by athletes and bodybuilders. Increased IGF-1 levels are also comparable to weight gain. This weight gain is a result of lean body mass growth, not fat production.
IGF-1 is favored in the bodybuilding industry and for people who workout regularly. It helps enhance recovery time after workout and improves energy during the workout.
IGF-1 injections are common for adults and children if they have a growth hormone deficiency. IGF-1 contains many necessary amino acids that can help children who are not developing at a standard rate and supplement adults that are deficient.
Research has also shown that the anabolic effects of IGF-1 may reflect inhibited protein breakdown and stimulated protein synthesis in skeletal muscle and that this response may be caused by a direct effect of IGF-1 on muscle tissue, therefore assisting burns on the skin and other tissue abnormalities.
Mechanism of Action
IGF-1 is a hormone found naturally in human blood. Its primary function is to manage the effects of growth hormone in the body. Normal IGF-1 and growth hormone functions include tissue and bone growth. IGF-1 is formed in different tissues as a result of growth hormone in the blood.
IGF-1 promotes systemic body growth, and has growth-stimulating effects on mostly every cell in the body, mainly bone, cartilage, skeletal muscle, liver, kidney, nerve, skin and lung cells. As well as the insulin-like effects, IGF-1 can also manage cellular DNA synthesis.
Administration
Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area. IGF-1 can also be administered intramuscularly.
Before administering IGF-1, always be sure to use a clean and sterile syringe.
Hold the IGF-1 vial upright and insert the syringe in the center of the cap.
Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
Before administering the syringe, use alcohol to cleanse the area of skin.
Pinch the skin around the area to be injected, leave about 2 cm on each side.
Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
Depress the plunger fully, until the syringe is empty, and carefully draw out.
Dosage
Dosage Amount: For lean muscle growth and fat loss
40 mcg - 50 mcg daily (men)
10 mcg - 20 mcg daily (women)
IGF-1 should not be injected more than twice daily
A typical dosage cycle of IGF-1 will continue for 2 to 12 weeks
Children and adults who are prescribed IGF-1 for development deficiency should consult with a care provider about correct dosing.
Side Effects
The side effects of IGF-1 can be similar to those of other growth hormones. These include growth of excess body tissue, also known as acromegaly, and damage to the joints, liver, and heart. IGF-1 could possibly cause joint pain, muscle pain, headaches and nausea. IGF-1 can also decrease levels of blood glucose, resulting in hypoglycemia. Researchers also associate IGF-1 with an increased risk of developing some cancers, such as lung, breast, colorectal and prostate.
Benefits
Facilitation of protein synthesis in the body
Regulation of stored fat and channeling it to be used for energy production, resulting in fat loss
Promotion of positive effects on metabolism and increasing lean body mass and muscle growth
Protection against autoimmune disease, heart disease and plaque buildup
Aid development in young children and adults deficient in essential amino acids
Improvement in blood sugar regulation
Promotion of optimal health, wellness and fitness in users | Eurigil (HCG) 5000IU is an injectable drug manufactured by Euro-Pharmacies and containing as active substance Human Chorionic Gonadotropin (hCG). This is a hormone produced during pregnancy that is made by the developing placenta after conception, and later by the placental component syncytiotrophoblast. One of the uses of hCG is to suppress hunger and trigger the human body’s use of fat for fuel. hCG is used also to cause ovulation and to treat infertility in women, and to increase sperm count in men. bodybuilders use it in steroids cycles and in post cycle therapy to lose gain and to increase Testosterone production.
Eurigil (HCG) 5000IU is utilized among bodybuilders and athletes at the end of an anabolic-androgenic steroid cycle to prevent the breakdown of muscle tissue. It is also important in restoring the testes to the normal abilities. Many times after a period of anabolic steroids usage the testes of an athlete may shrink. Pregnyl is effective in returning them to normal size. When used along with a very low-calorie diet, athletes burn off that extra fat over their muscle mass. Females may also use Pregnyl with a very low calorie diet to burn off unnecessary fat.
The average dosage of Eurigil (HCG) 5000IU during a cycle is between 500iu to 3000iu every week (1-3 times per week). If the injection is taken more frequently the blood level of the athlete are more stable while taking it in one shot may increase the estrogen levels caused by the aromatization of normal Testosterone and result in gynecomastia. There are sources showing that some bodybuilders used 6000iu for 6 days, but this is a risky affair and depend on the individual features of men. As post cycle therapy Pregnyl should be used in smaller doses, about 250 – 500iu every day for 2 or 3 weeks. Smaller doses are enough to begin reversal process of testicular atrophy. When starting a cycle of hCG, bodybuilders must follow it for 2 to 3 week range with a least one month off in between and follow this course with no concern. Pregnyl can be used with Clomid or Nolvadex in the PCT and continue using them after HCG is no longer part of the cycle. It is also recommended to start and hCG cycle near the end of a normal steroids cycle, most effective in the last week.
The most serious side effects that may occur while using Eurigil (HCG) 5000IU are: severe pelvic pain, swelling of the hands or legs, stomach pain and swelling, shortness of breath, weight gain, diarrhea, nausea or vomiting. Other common side effects of Pregnyl are: headache, feeling restless or irritable, mild swelling or water weight gain, depression, breast tenderness or swelling; or pain, swelling, or irritation where the injection is given. Among boys the medicine can cause early signs of puberty, such as a deepened voice, pubic hair growth, and increased acne or sweating. |
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