|Content||Growth Hormone peptide fragment 176-191, also known as HGH Frag 176-191, is a modified form of amino acids 176-191 of the GH polypeptide. It works by mimicking the way natural Growth Hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Growth Hormone.
The recommended duration of use of HGH Fragment 2-3 months, then it is recommended to break. The maximum recommended daily dose for the fastest effect is 2,000 mcg, divided into 3-5 applications.
HGH fragment may be used alone, but is also well combinable with several other peptides.
HGH Fragment 176-191 Stack/Cycle
The compound can be stacked with T3 and Clenbuterol to obtain results in fat loss and increase of muscular mass. Some steroid users report that they stack HGH Fragment 176-191 with Deca Durabolin and Testoxyl Propionate for effective for cutting results.||CJC-1295 is a synthetic GHRH (growth hormone releasing hormone) analogue made up of 30 amino acids. It has been found to be highly effective with regards to the increase of growth hormone secretion and IGF-1 without negatively affecting the pulsatility of GH secretion.
CJC-1295 is often combined with Ipamorelin due to its enhanced specificity as a GHRH. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated and perfect when combined with Ipamorelin.
Gland Stimulated: Pituitary
Benefits of CJC-1295:
Increased growth hormone secretion and IGF-1 Levels with no increase in prolactin
Increased Body Weight and Length through increased protein synthesis
Increased Muscle Growth
Increased Bone Density
Improved Immune Function
Improved Cognition and Memory
Increased Collagen Production
Increased Fat Loss
Increased Cellular Repair and Regeneration
CJC-1295 also promotes slow wave deep sleep, which is responsible for the highest level of muscle growth and memory retention and rejuvenation
Two types of CJC 1295:
GHRH (growth hormone releasing hormone) is produced in the hypothalamus. Its pulsatile release from the hypothalamus triggers a pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life = the time required to remove half of the substance from the blood. The shorter the half-life, the more rapidly the substance is removed from the body, and the less its effect on the body).
The first 29 amino acids of GHRH is the active segment. They are available as a manufactured peptide called Sermorelin. Sermorelin was further modified to increase its half-life to 30 minutes. This is called CJC 1295. CJC-1295 was further modified by adding DAC (Drug Affinity Complex) to it. DAC binds to a blood protein called albumin, which increases it's half-life to 8 days. It is called CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form which mimics a more normal physiologic GH spike each night.
The longer half-life from the DAC binding to albumin means injections are only required once or twice per week. However, the long half-life and relatively constant blood level provide a constant stimulus for GH release from the pituitary through the GHRH receptor, which is not physiological. This can decrease the GH pulse amplitude which will result in decreased GH tissue stimulation.
It is recommended when using a long-acting CJC molecule to have 'hormone holidays' of three months each three to six months, to allow the pituitary to 'recover'. During the holidays, Sermorelin is used instead of CJC 1295 + DAC.
The 'hormone holidays' may also minimize the risk of GH resistance developing. This resistance, or insensitivity, may occur via antibodies forming that bind to and inactivate GH, or by a decreased number of GH receptors on tissues (down-regulation). These are theoretical concerns as no long-term studies have been undertaken to clarify the issues.
Side effects of CJC-1295 may include injection site reactions (irritation, erythema, induration, pain, itching), headache, diarrhea, vasodilation (flushing, warmth, transient hypotension), nausea, abdominal pain.||This peptide CJC-1295 NO-DAC imitates the function of GHRF or Growth Hormone Releasing Factors by which it increases and enhances the release of Growth Hormones in the Body. Use this from 1mg-2mg for 5 days out of 7 days from 6pm-8pm for best results.||Ipamorelin is a pentapeptide and a ghrelin mimetic with growth hormone releasing activity.
Ipamorelin imitates ghrelin and ties to the ghrelin receptor in the brain, thus selectively stimulating the release of growth hormone from the pituitary gland.
Growth hormones are frequently released and more abundant in children. When humans begin to age, the production of growth hormones decelerates and lessens gradually over time. The use of Ipamorelin can encourage these growth hormones to be created and released regularly.
Ipamorelin is used to help increase growth hormone production, which can assist in the reduction of body fat, enhancement of lean muscle mass, improvement of sleep, and increase of energy and over all wellness.
Ipamorelin is mostly used for collagen production, wrinkle reduction, acceleration of healing and recovery, and enhancement of mood and sleep; therefore being a peptide that is sought after for it’s anti-aging benefits.
Mechanism of Action
The function of Ipamorelin is to mimic ghrelin. The hormone ghrelin, discovered in 1999, has extreme effects on metabolism, restraining stored fat breakdown, and most importantly gherlin performs to regulate growth hormone release from the pituitary gland.
Ipamorelin fastens to ghrelin receptors on the pituitary gland, activating them identically to the way ghrelin naturally would. The activation of these receptors work collectively with no effect on the rest of the body’s hormones.
Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area.
Before administering Ipamorelin, always be sure to use a clean and sterile syringe.
Hold the Ipamorelin vial upright and insert the syringe in the center of the cap.
Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
Before administering the syringe, use alcohol to cleanse the area of skin.
Pinch the skin around the area to be injected, leave about 2 cm on each side.
Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
Depress the plunger fully, until the syringe is empty, and carefully draw out.
Dosage Amount: 100mcg - 500mcg (0.1mg to 0.5mg)
Dosage Frequency: 1-3 times daily
Recommended dose of 300mcg, 3 times daily (injection under the skin) for strength gain and performance enhancement
Recommended dose of 200mcg, 1 time daily (injection under the skin) for anti-aging purposes
For best results, it is recommended to administer Ipamorelin at the same time daily. Avoid consumption of food and liquids at least one hour before and after administering Ipamorelin.
Ipamorelin typically takes time to show results. While some patients will notice significant changes in the body after the first month, the full-benefits are usually noticed after three to six months of administering the peptide daily.
Ipamorelin is most successful with diet, exercise, consistency and time.
The most common reaction to Ipamorelin is redness and irritation around the injection site. This reaction is typically short term and normally goes away on its own.
Ipamorelin is can also increase hunger and cause dry mouth in some patients.
In less than 1% of patients that use Ipamorelin, other side effects have occurred, including: severe drowsiness, hives, vomiting, headache, nausea, difficulty swallowing, hyperactivity, chest tightness and pallor, distortion in perception of taste, and flushing of the skin.
Anti-aging: collagen production and wrinkle reduction
Increase of lean muscle mass and muscle growth
Accelerated recovery time from exercising, weight lifting and physical activity
Improvement in cellular repair and regeneration
Increase of energy, the immune system and overall wellness
Improvement in bone strength and bone mineral density composite
Higher metabolic rate and improved circulation resulting in body fat reduction
Improvement in sleep cycle, resulting in heightened mood and energy||CJC-1295 DAC, also known as growth hormone releasing factor (GRF MOD (1-29) or GRF), is an analogue of GHRH (growth hormone releasing hormone).
CJC-1295 is a GHRH (the 44-amino acid long version) with 15 aminos removed, thus a total of 29 amino acids, and bound to DAC it is also called Drug Affinity Complex, and CJC-1295 is often referred to as GHRH with Drug Affinity Complex, this essentially lengthens its life span.
The difference between CJC-1295 and CJC-1295 DAC is that CJC-1295 DAC version CJC-1295 with the addition of so-called. Drug Affinity Complex (DAC), which significantly prolong their effects and action. This means that the product will act in the body much longer than is usual in CJC-1295 (without DAC), namely up to 14 days.
The main effects of CJC-1295 DAC
enhances secretion of growth hormone in the blood;
helps achieve significant muscle hardness;
promotes muscle growth and strength;
helps burn fat effectively;
visibly improves skin quality, has a rejuvenating effect and smooths wrinkles;
increases bone density;
effectively strengthens ligaments and joints;
has a significant positive effect on sleep, regeneration and vitality.
CJC 1295 DAC Stack/Cycle
In order to regenerate the various systems of the body, take CJC-1295 just before going to bed, once per day.
In bodybuilding, for muscle building, a CJC-1295 injection is produced three times a day.
The optimum dose is considered to be 300 mcg per day and it should be divided into three equal parts, to perform injections in the morning, afternoon and evening.
In order to achieve a synergistic effect, in which substantially increases the release of growth hormone, it is practiced co-administration of CJC-1295 and GHRP-2 or GHRP-6.
Duration of CJC-1295 cycle does not have any limitations.
The drug is injected into the body via intramuscular or subcutaneous injection.|