|Content||Insulin-like growth factor-1 (IGF-1) helps encourage normal bone and tissue growth and development and also has the ability to decrease blood glucose levels.
IGF-1 advances to fat cells and therefore burns fat. Subsequently, it increases lean body mass and decreases fat. These effects are desired mostly by athletes and bodybuilders. Increased IGF-1 levels are also comparable to weight gain. This weight gain is a result of lean body mass growth, not fat production.
IGF-1 is favored in the bodybuilding industry and for people who workout regularly. It helps enhance recovery time after workout and improves energy during the workout.
IGF-1 injections are common for adults and children if they have a growth hormone deficiency. IGF-1 contains many necessary amino acids that can help children who are not developing at a standard rate and supplement adults that are deficient.
Research has also shown that the anabolic effects of IGF-1 may reflect inhibited protein breakdown and stimulated protein synthesis in skeletal muscle and that this response may be caused by a direct effect of IGF-1 on muscle tissue, therefore assisting burns on the skin and other tissue abnormalities.
Mechanism of Action
IGF-1 is a hormone found naturally in human blood. Its primary function is to manage the effects of growth hormone in the body. Normal IGF-1 and growth hormone functions include tissue and bone growth. IGF-1 is formed in different tissues as a result of growth hormone in the blood.
IGF-1 promotes systemic body growth, and has growth-stimulating effects on mostly every cell in the body, mainly bone, cartilage, skeletal muscle, liver, kidney, nerve, skin and lung cells. As well as the insulin-like effects, IGF-1 can also manage cellular DNA synthesis.
Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area. IGF-1 can also be administered intramuscularly.
Before administering IGF-1, always be sure to use a clean and sterile syringe.
Hold the IGF-1 vial upright and insert the syringe in the center of the cap.
Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
Before administering the syringe, use alcohol to cleanse the area of skin.
Pinch the skin around the area to be injected, leave about 2 cm on each side.
Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
Depress the plunger fully, until the syringe is empty, and carefully draw out.
Dosage Amount: For lean muscle growth and fat loss
40 mcg - 50 mcg daily (men)
10 mcg - 20 mcg daily (women)
IGF-1 should not be injected more than twice daily
A typical dosage cycle of IGF-1 will continue for 2 to 12 weeks
Children and adults who are prescribed IGF-1 for development deficiency should consult with a care provider about correct dosing.
The side effects of IGF-1 can be similar to those of other growth hormones. These include growth of excess body tissue, also known as acromegaly, and damage to the joints, liver, and heart. IGF-1 could possibly cause joint pain, muscle pain, headaches and nausea. IGF-1 can also decrease levels of blood glucose, resulting in hypoglycemia. Researchers also associate IGF-1 with an increased risk of developing some cancers, such as lung, breast, colorectal and prostate.
Facilitation of protein synthesis in the body
Regulation of stored fat and channeling it to be used for energy production, resulting in fat loss
Promotion of positive effects on metabolism and increasing lean body mass and muscle growth
Protection against autoimmune disease, heart disease and plaque buildup
Aid development in young children and adults deficient in essential amino acids
Improvement in blood sugar regulation
Promotion of optimal health, wellness and fitness in users||This peptide CJC-1295 CJC-1295 W-DAC 2MG is also an artificial growth hormone. This is one of the best hormone because of its versatility and can be used in muscle build-up, weight gain, weight loss, anti-aging, and increasing in growth hormones. Take this from 0.5mg-2mg per week 20 at anytime of the day. Inject this 20 minutes prior to eating.
||MGF is an acronym for Mechano Growth Factor. This may be a chemical that many users of conventional drugs do not recognise. This is because it is a replica of a very specific molecular signal and an offshoot of the Insulin-like Growth Factor 1 (IGF-1).
As such, this item is usually only used by more seasoned practitioners looking to boost recovery and subsequent gains in muscle strength, power and mass.
This is because Mechano Growth Factor is a molecular signal used in the body to signal surrounding cells, known as “satellite cells”, to migrate into the muscle and become part of the muscle cell.
This creates a bigger muscle cell and can permanently increase the potential size and force capacity of a given muscle fibre. Therefore it may help improve an athlete’s potential even after a user has stopped including it in their regimen.
So, it is no wonder why many individuals, like aesthetic competitors or sportspeople, seek out the Mechano Growth Factor 2 mg peptide.
However, because of its relative lack of therapeutic uses, compared to other items for those with medical ailments or those who don’t utilise it for the above reasons, it is incredibly difficult to find this item from conventional vendors such as pharmacies or medical facilities.
This means that, if you are looking for these types of agents, you’ll have to buy peptides online, much like many other similar chemicals which are used for related purposes.
However, before getting this, or any other similar item, it is key to understand how this item may be included in a regime in order to get the desired outcomes for which it is acquired. So, below, we look at how this agent is commonly included in regimens, how much of it is used, as well as when, and potential drawbacks to its inclusion in your programme.
Mechano Growth Factor Peptide Doses and Timing
There is a relative scarcity of research looking at what MGF peptide dosage is most ideal for those using it purely to boost size or athletic capability.
However, larger amounts have been reported to produce better outcomes than smaller ones. In terms of a commonly reported amount, the MGF 2mg thrice weekly over a period of four weeks has been used by many of those looking for athletic or structural benefit.
In terms of timing these MGF doses, this agent is usually administered immediately after a workout. The reason for this is due to the relatively short half-life of the chemical, which has a half-life lasting only a few minutes. This means it will be broken down and processed by the body only a few minutes after it has been administered.
So, users choose to administer it directly after a workout where the body is in the process of renewal and repair and anabolic signalling will be strong. But, if administering this item immediately after a workout is not a viable option for some, then the best alternative would be to instead include an esterified form of the agent such as MGF-PEG, which has a polyethylene glycol attachment to extend its half-life to several days.
This can afford a more gradual release and processing of the agent in the body and allows a lot more freedom of when the Mechano Growth Factor can be administered.
The above information should help you select the form of the chemical best suited to your needs and lifestyle, as well as how best to use your form in an attempt to maximize your results from the agent. Now, we can look at the potential adverse events associated with the use of this agent that should be considered when looking at getting it for your regimen.
MGF Peptide Side Effects
Much like the perks behind the use of this agent, research looking at the adverse events associated with the use of this growth factor, or other related new items such as fragment 176-191, particularly for the purposes listed in the above sections, is very thin.
This makes it hard to outline the range of drawbacks that may impact the vast majority of users.
However, from reviewing reports from previous users and suppliers, some MGF peptide side effects can include:
Pain or irritation surrounding the site of administration, as is common with a lot of injectable solutions;
Potential cardiac issues or irregularities.
These should all be considered before you buy MGF peptide to ensure you are on the lookout for any particular issues with use and ensure an enjoyable, effective and efficient period of use.||Eurigil (HCG) 5000IU is an injectable drug manufactured by Euro-Pharmacies and containing as active substance Human Chorionic Gonadotropin (hCG). This is a hormone produced during pregnancy that is made by the developing placenta after conception, and later by the placental component syncytiotrophoblast. One of the uses of hCG is to suppress hunger and trigger the human body’s use of fat for fuel. hCG is used also to cause ovulation and to treat infertility in women, and to increase sperm count in men. bodybuilders use it in steroids cycles and in post cycle therapy to lose gain and to increase Testosterone production.
Eurigil (HCG) 5000IU is utilized among bodybuilders and athletes at the end of an anabolic-androgenic steroid cycle to prevent the breakdown of muscle tissue. It is also important in restoring the testes to the normal abilities. Many times after a period of anabolic steroids usage the testes of an athlete may shrink. Pregnyl is effective in returning them to normal size. When used along with a very low-calorie diet, athletes burn off that extra fat over their muscle mass. Females may also use Pregnyl with a very low calorie diet to burn off unnecessary fat.
The average dosage of Eurigil (HCG) 5000IU during a cycle is between 500iu to 3000iu every week (1-3 times per week). If the injection is taken more frequently the blood level of the athlete are more stable while taking it in one shot may increase the estrogen levels caused by the aromatization of normal Testosterone and result in gynecomastia. There are sources showing that some bodybuilders used 6000iu for 6 days, but this is a risky affair and depend on the individual features of men. As post cycle therapy Pregnyl should be used in smaller doses, about 250 – 500iu every day for 2 or 3 weeks. Smaller doses are enough to begin reversal process of testicular atrophy. When starting a cycle of hCG, bodybuilders must follow it for 2 to 3 week range with a least one month off in between and follow this course with no concern. Pregnyl can be used with Clomid or Nolvadex in the PCT and continue using them after HCG is no longer part of the cycle. It is also recommended to start and hCG cycle near the end of a normal steroids cycle, most effective in the last week.
The most serious side effects that may occur while using Eurigil (HCG) 5000IU are: severe pelvic pain, swelling of the hands or legs, stomach pain and swelling, shortness of breath, weight gain, diarrhea, nausea or vomiting. Other common side effects of Pregnyl are: headache, feeling restless or irritable, mild swelling or water weight gain, depression, breast tenderness or swelling; or pain, swelling, or irritation where the injection is given. Among boys the medicine can cause early signs of puberty, such as a deepened voice, pubic hair growth, and increased acne or sweating.||CJC-1295 is a synthetic GHRH (growth hormone releasing hormone) analogue made up of 30 amino acids. It has been found to be highly effective with regards to the increase of growth hormone secretion and IGF-1 without negatively affecting the pulsatility of GH secretion.
CJC-1295 is often combined with Ipamorelin due to its enhanced specificity as a GHRH. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated and perfect when combined with Ipamorelin.
Gland Stimulated: Pituitary
Benefits of CJC-1295:
Increased growth hormone secretion and IGF-1 Levels with no increase in prolactin
Increased Body Weight and Length through increased protein synthesis
Increased Muscle Growth
Increased Bone Density
Improved Immune Function
Improved Cognition and Memory
Increased Collagen Production
Increased Fat Loss
Increased Cellular Repair and Regeneration
CJC-1295 also promotes slow wave deep sleep, which is responsible for the highest level of muscle growth and memory retention and rejuvenation
Two types of CJC 1295:
GHRH (growth hormone releasing hormone) is produced in the hypothalamus. Its pulsatile release from the hypothalamus triggers a pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life = the time required to remove half of the substance from the blood. The shorter the half-life, the more rapidly the substance is removed from the body, and the less its effect on the body).
The first 29 amino acids of GHRH is the active segment. They are available as a manufactured peptide called Sermorelin. Sermorelin was further modified to increase its half-life to 30 minutes. This is called CJC 1295. CJC-1295 was further modified by adding DAC (Drug Affinity Complex) to it. DAC binds to a blood protein called albumin, which increases it's half-life to 8 days. It is called CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form which mimics a more normal physiologic GH spike each night.
The longer half-life from the DAC binding to albumin means injections are only required once or twice per week. However, the long half-life and relatively constant blood level provide a constant stimulus for GH release from the pituitary through the GHRH receptor, which is not physiological. This can decrease the GH pulse amplitude which will result in decreased GH tissue stimulation.
It is recommended when using a long-acting CJC molecule to have 'hormone holidays' of three months each three to six months, to allow the pituitary to 'recover'. During the holidays, Sermorelin is used instead of CJC 1295 + DAC.
The 'hormone holidays' may also minimize the risk of GH resistance developing. This resistance, or insensitivity, may occur via antibodies forming that bind to and inactivate GH, or by a decreased number of GH receptors on tissues (down-regulation). These are theoretical concerns as no long-term studies have been undertaken to clarify the issues.
Side effects of CJC-1295 may include injection site reactions (irritation, erythema, induration, pain, itching), headache, diarrhea, vasodilation (flushing, warmth, transient hypotension), nausea, abdominal pain.|
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