Meldonix

$162.00

Availability: Out of Stock

ACTIVE HALF-LIFE 24 hours
TABLET COUNT: 50 COUNTS
 CLASSIFICATION Fatty Acid Oxidation Inhibitor
 DOSAGE 250-1000 mg/day
 ACNE No
 WATER RETENTION No
 HBR Possible
 HEPATOTOXICITY No
 AROMATIZATION No

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SKU: EURO29798 Categories: , , ,

Description

What is Meldonium?

Meldonium is used clinically to treat angina and myocardial infarction. The first clinical trial testing the efficacy of using a combination of meldonium and lisinopril, an angiotensin-converting enzyme inhibitor, to treat chronic heart failure, was reported in 2005, and concluded that the combination of meldonium and lisinopril may improve the quality of life, exercise capacity, and mechanisms of peripheral circulation of patients with chronic heart failure.

Uses

Treat Chronic Heart Failure and Cerebral Strokes
Abstinence Syndrome
Improves Oxygen Delivery to Cells
Protects Cells from Intoxication
Excellent for Sportsmen to Improve Stamina
Improves Energy Levels and Faster Physical Recovery
What should my health care professional know before I take this medicine?

Contraindications

Hypersensitivity to meldonium or any components of the drug. Increased intracranial pressure (in case of impaired venous drainage, intracranialtumours). Pregnancy and breast-feeding periods. Children’s age.

Patients with chronic liver and renal diseases should take care in case of long-term application of the drug. Due to possible development of stimulating effect it is recommended to take the drug before noon.

How should I take this medicine?

Applied internally.
• Intellectual and physical stress (including in athletes). Adults – 1 g per day divided into two 500mg doses. Course of treatment is 10-14 days. If necessary, the treatment is repeated in 2-3 weeks.
• Athletes should take 500 mg – 1 g twice a day before training. Duration of treatment during preparatory period is 2-3 weeks, during the period of
competition – 10-14 days.
• Cardiovascular disease. As part of combined therapy: 500 mg -1 g (2-4 tablets) per day, taking the whole dose at one time or dividing for 2 takings. Course of treatment is 4-6 weeks.
• Cardialgia against the background of dyshormonal myocardiodystrophy – 500 mg per day. Course of treatment is 12 days.
• Disturbed cerebral circulation. In course of treatment after elimination of acute disorders: 500 mg – 1 g per day, taking the whole dose at one time or dividing it for 2 takings. In case of chronic disorders: 500 mg per day. General course of treatment is 4-6 weeks. Recurrent courses (usually 2-3 times a year) may be taken after consulting a doctor.
• Diseases of peripheral arteries. 500 mg twice a day.
• Abstinence syndrome in case of chronic alcoholism. 500 mg 4 times a day. Course of treatment is 7-10 days.
• Maximum daily dose is 2000 mg.

Interaction with other drugs and other types of interaction

The drug may be combined with antianginal agents, anticoagulants and antiaggregants, antiarrhythmic drugs, diuretics, and bronchial spasmolytics. It intensifies the action of coronary vasodilating drugs, some hypotensive agents, and cardiac glycosides. Taking into consideration the possible development of mild tachycardia and arterial hypotension, care should be taken when combining the drug with nitroglycerin, nifediphine, alpha-adrenoceptor blockers, hypotensive agents and peripheral vasodilators.

Application during pregnancy and breast-feeding periods

Safety of Mildronate application during the pregnancy period has not been proved. In order to avoid possible negative effect of the drug on foetus, it should not be applied during pregnancy. It is unknown whether the drug penetrates into breast milk. If mother requires treatment with Mildronate, breast-feeding shall be stopped.

Storage:

Keep away from direct sunlight.
Keep locked and away from children.
Store in dry place at room temperature.
Do not exceed storage temperature higher than 25 C

What side effects may I notice when taking this medicine?

Rarely – allergic reactions (redness, rash, itching, oedema), as well as dyspepsia, tachycardia, excitement, changes of arterial pressure.

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SettingsMeldonix removeStanzone - Stanozolol 10mg. removeExemestane 25mg - Hilma Biocare removeProvimed 25mg – Mesterolone – Deus Medical removeLetrozone - Letrozole 5mg/100 tabs. removeAromamed 25mg – Exemestane – Deus Medical remove
NameMeldonix removeStanzone - Stanozolol 10mg. removeExemestane 25mg - Hilma Biocare removeProvimed 25mg – Mesterolone – Deus Medical removeLetrozone - Letrozole 5mg/100 tabs. removeAromamed 25mg – Exemestane – Deus Medical remove
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DescriptionACTIVE HALF-LIFE 24 hours TABLET COUNT: 50 COUNTS  CLASSIFICATION Fatty Acid Oxidation Inhibitor  DOSAGE 250-1000 mg/day  ACNE No  WATER RETENTION No  HBR Possible  HEPATOTOXICITY No  AROMATIZATION NoActive Ingredient: Stanozolol 10mg Tablet Count: 100 tabs Active Half-life: 9 Hours Classification: Anabolic Steroid Dosage Men: 20-50 Mg/day Acne: Yes Water Retention: No Hbr: perhaps Hepatoxicity: yes Aromatization: No Ship From: USAACTIVE INGREDIENT: Exemestane 25 mg TABLET COUNT: 30 COUNTS ACTIVE HALF-LIFE: 9 HOURS CLASSIFICATION: ANABOLIC STEROID DOSAGE MEN: 25-50 MG/DAY DOSAGE WOMEN: 5-30 MG/DAY ACNE: RARELY WATER RETENTION: NO HBR: NO HEPATOXITY: LOW Ship From: EuropeActive Ingredient: Mesterolone 10mg Bottle Count: 50 Tablets Active Half-life: 12 Hours Classification: Anabolic Steroid Dosage Men: 30-100 mg/day Acne: Yes Water Retention: No Concentration: 10 mg/Pill Presentation: 50 Tablets (Total box 500 mg) Dosage: 30-100mg per day over the course of 8-12 weeksACTIVE INGREDIENT: LETROZOLE 5mg TABLET COUNT: 100 COUNTS ACTIVE HALF-LIFE: 9 HOURS CLASSIFICATION: ANTI ESTROGEN DOSAGE: 5mg ACNE: NONE WATER RETENTION: NO HBR: NO HEPATOXITY: LOW AROMATIZATION: NOActive Ingredient: Exemestane 25 Mg Tablet Count: 25 Counts Active Half-life: 9 Hours Classification: Anabolic Steroid Dosage Men: 25-50 Mg/day Dosage Women: 5-30 Mg/day Acne: Rarely Water Retention: No Hbr: No Hepatoxity: Low
ContentWhat is Meldonium? Meldonium is used clinically to treat angina and myocardial infarction. The first clinical trial testing the efficacy of using a combination of meldonium and lisinopril, an angiotensin-converting enzyme inhibitor, to treat chronic heart failure, was reported in 2005, and concluded that the combination of meldonium and lisinopril may improve the quality of life, exercise capacity, and mechanisms of peripheral circulation of patients with chronic heart failure. Uses Treat Chronic Heart Failure and Cerebral Strokes Abstinence Syndrome Improves Oxygen Delivery to Cells Protects Cells from Intoxication Excellent for Sportsmen to Improve Stamina Improves Energy Levels and Faster Physical Recovery What should my health care professional know before I take this medicine? Contraindications Hypersensitivity to meldonium or any components of the drug. Increased intracranial pressure (in case of impaired venous drainage, intracranialtumours). Pregnancy and breast-feeding periods. Children’s age. Patients with chronic liver and renal diseases should take care in case of long-term application of the drug. Due to possible development of stimulating effect it is recommended to take the drug before noon. How should I take this medicine? Applied internally. • Intellectual and physical stress (including in athletes). Adults – 1 g per day divided into two 500mg doses. Course of treatment is 10-14 days. If necessary, the treatment is repeated in 2-3 weeks. • Athletes should take 500 mg – 1 g twice a day before training. Duration of treatment during preparatory period is 2-3 weeks, during the period of competition – 10-14 days. • Cardiovascular disease. As part of combined therapy: 500 mg -1 g (2-4 tablets) per day, taking the whole dose at one time or dividing for 2 takings. Course of treatment is 4-6 weeks. • Cardialgia against the background of dyshormonal myocardiodystrophy – 500 mg per day. Course of treatment is 12 days. • Disturbed cerebral circulation. In course of treatment after elimination of acute disorders: 500 mg – 1 g per day, taking the whole dose at one time or dividing it for 2 takings. In case of chronic disorders: 500 mg per day. General course of treatment is 4-6 weeks. Recurrent courses (usually 2-3 times a year) may be taken after consulting a doctor. • Diseases of peripheral arteries. 500 mg twice a day. • Abstinence syndrome in case of chronic alcoholism. 500 mg 4 times a day. Course of treatment is 7-10 days. • Maximum daily dose is 2000 mg. Interaction with other drugs and other types of interaction The drug may be combined with antianginal agents, anticoagulants and antiaggregants, antiarrhythmic drugs, diuretics, and bronchial spasmolytics. It intensifies the action of coronary vasodilating drugs, some hypotensive agents, and cardiac glycosides. Taking into consideration the possible development of mild tachycardia and arterial hypotension, care should be taken when combining the drug with nitroglycerin, nifediphine, alpha-adrenoceptor blockers, hypotensive agents and peripheral vasodilators. Application during pregnancy and breast-feeding periods Safety of Mildronate application during the pregnancy period has not been proved. In order to avoid possible negative effect of the drug on foetus, it should not be applied during pregnancy. It is unknown whether the drug penetrates into breast milk. If mother requires treatment with Mildronate, breast-feeding shall be stopped. Storage: Keep away from direct sunlight. Keep locked and away from children. Store in dry place at room temperature. Do not exceed storage temperature higher than 25 C What side effects may I notice when taking this medicine? Rarely – allergic reactions (redness, rash, itching, oedema), as well as dyspepsia, tachycardia, excitement, changes of arterial pressure.Stanozolol 10mg x 100 tablets Stanzolol is a derivative of dihydrotestosterone, although its activity is much milder than this androgen in nature. It is technically classified as an anabolic steroid, shown to exhibit a slightly greater tendency for muscle growth than androgenic activity in early studies.Exemestane is a synthetic androgen analogue. It’s is a steroidal inhibitor of aromatase which  binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. Exemestane has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury. This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Exemestane decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers. Exemestane is usually not used in women of childbearing age. Exemestane is usually taken once a day after a meal. Take Exemestane at around the same time every day. You may need to take Exemestane for several years or longer. Continue to take Exemestane even if you feel well. Do not stop taking Exemestane without talking to your doctor. Effect On Estrogens Plasma estrogen (estradiol, estrone, and estrone sulfate) suppression is seen starting at a 5-mg daily dose of Exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose. Exemestane 25 mg daily reduces whole body aromatization (as measured by injecting radiolabeled androstenedione) by 98% in postmenopausal women with breast cancer. After a single dose of Exemestane 25 mg, the maximal suppression of circulating estrogens occurres 2 to 3 days after dosing and persisted for 4 to 5 days. Effect On Corticosteroids In multiple-dose trials of doses up to 200 mg daily, Exemestane selectivity was assessed by examining its effect on adrenal steroids. Exemestane did not affect cortisol or aldosterone secretion at baseline or in response to ACTH at any dose. Thus, no glucocorticoid or mineralocorticoid replacement therapy is necessary with Exemestane treatment. Other Endocrine Effects Exemestane does not bind significantly to steroidal receptors, except for a slight affinity for the androgen receptor (0.28% relative to dihydrotestosterone). The binding affinity of its 17dihydrometabolite for the androgen receptor, however, is 100 times that of the parent compound. Daily doses of Exemestane up to 25 mg had no significant effect on circulating levels of androstenedione, dehydroepiandrosterone sulfate, or 17-hydroxyprogesterone, and were associated with small decreases in circulating levels of testosterone. Increases in testosterone and androstenedione levels have been observed at daily doses of 200 mg or more. A dose-dependent decrease in sex hormone binding globulin (SHBG) has been observed with daily Exemestane doses of 2.5 mg or higher. Slight, nondose-dependent increases in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels have been observed even at low doses as a consequence of feedback at the pituitary level. Exemestane 25 mg daily had no significant effect on thyroid function [free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH). Absorption Exemestane is distributed extensively into tissues. Exemestane is 90% bound to plasma proteins and the fraction bound is independent of the total concentration. Albumin and α11-acid glycoprotein both contribute to the binding. The distribution of Exemestane and its metabolites into blood cells is negligible. Metabolism Exemestane is extensively metabolized. The initial steps in the metabolism of Exemestane are oxidation of the methylene group in position 6 and reduction of the 17-keto group with subsequent formation of many secondary metabolites. Each metabolite accounts only for a limited amount of drug-related material. The metabolites are inactive or inhibit aromatase with decreased potency compared with the parent drug. One metabolite may have androgenic activity [see Pharmacodynamics]. Studies using human liver preparations indicate that cytochrome P 450 3A4 (CYP 3A4) is the principal isoenzyme involved in the oxidation of Exemestane. Exemestane is metabolized also by aldoketoreductases.Letrozole 5mg x 100 tablets Letrozole is a third generation Aromatase Inhibitor (AI) that works by attaching to -and eliminating the aromatase enzyme resposible for producing estrogen. This makes it a perfect choice to combat gynocomastia which it will completely prevent. Letrozole also quite raises LH levels which deems it suitable for post-cycle use. The human body does need estrogen to maintain proper immune function and balance cholesterol ratios in the blood. Since letrozole is so strong at eliminating estrogen, it is not suited for long term use.
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