|Content||Oxytocin is a hormone secreted by the posterior lobe of the pituitary gland, a pea-sized structure at the base of the brain.
It's sometimes known as the "cuddle hormone" or the "love hormone," because it is released when people snuggle up or bond socially. Even playing with your dog can cause an oxytocin surge, according to a 2009 study published in the journal Hormones and Behavior. But these monikers may be misleading.
Oxytocin can also intensify memories of bonding gone bad, such as in cases where men have poor relationships with their mothers. It can also make people less accepting of people they see as outsiders. In other words, whether oxytocin makes you feel cuddly or suspicious of others depends on the environment.
Oxytocin in women
Oxytocin is a particularly important hormone for women. "Oxytocin is a peptide produced in the brain that was first recognized for its role in the birth process, and also in nursing," said Larry Young, a behavioral neuroscientist at Emory University in Atlanta, Georgia.
The hormone causes uterine contractions during labor and helps shrink the uterus after delivery. When an infant suckles at his or her mother's breast, the stimulation causes a release of oxytocin, which, in turn, orders the body to "let down" milk for the baby to drink.
Oxytocin also promotes mother-child bonding. Studies show that "female rats find pups to be aversive if [the females are] virgins," Young told Live Science. "But once they give birth, the brain is transformed, so they find the pups irresistible," he said. And similar findings are seen in humans.
A 2007 study published in the journal Psychological Science found that the higher a mom's oxytocin levels in the first trimester of pregnancy, the more likely she was to engage in bonding behaviors such as singing to or bathing her baby. [11 Interesting Effects of Oxytocin]
Although maternal bonding may not always be hardwired — after all, human females can adopt babies and take care of them — oxytocin released during pregnancy "does seem to have a role in motivation and feelings of connectedness to a baby," Young said. Studies also show that interacting with a baby causes the infant's own oxytocin levels to increase, he added.
Oxytocin in men
In men, as in women, oxytocin facilitates bonding. Dads who got a boost of oxytocin via a nasal spray played more closely with their 5-month-old babies than dads who didn't get the hormone zap, a 2012 study found. (There is another hormone, called vasopressin, which plays a stronger role in men.)
This anti-social effect of a social hormone brings some nuance to the story of oxytocin. In one study, researchers found that Dutch students given a snort of the hormone became more positive about fictional Dutch characters, but were more negative about characters with Arab or German names. The finding suggests that oxytocin's social bonding effects are targeted at whomever a person perceives as part of their in-group, the researchers reported in January 2011 in the journal PNAS.
In another study, published in PNAS in 2010, men were given a dose of oxytocin and asked to write about their mothers. Those with secure relationships described their moms as more caring after the hormone dose. Those with troubled relationships actually saw their mothers as less caring. The hormone may help with the formation of social memories, according to the study researchers, so a whiff strengthens previous associations, whether good or bad.
"My view of what oxytocin is doing in the brain is making social information more salient," Young said. "It connects brain areas involved in processing social information — whether it's sights, faces, sounds or smells — and helps link those areas to the brain's reward system."
Oxytocin sprays and side effects
Oxytocin nose sprays also have been considered for use in treating autism. The neurological disorder is marked by struggles with social functioning, so a small 2013 study published in the journal PNAS gave a dose to children and teens with autism and asked the participants to identify emotions based on pictures of people's eyes.
The participants weren't any better at identifying the emotions after the oxytocin burst, but the regions of their brains associated with social interaction became more active. The increased processing could mean that a burst of oxytocin might help cement behavioral therapy for kids with the disorder.
"When you think about using oxytocin to treat diseases like autism, you want to make sure you do it in a context where the social information is positive," Young said.
Use of oxytocin sprays outside of a medical context is far murkier, however. The sprays sold online without a prescription promise stress relief and social ease, but they are not regulated by the Food and Drug Administration (FDA). That means that nothing is known about their efficacy, side effects, or even whether they contain any oxytocin.
There are no long-term studies on the side effects of the legitimate oxytocin sprays used in hormone research; most studies give people one dose of the hormone only. Pitocin, a synthetic version of oxytocin given intravenously to stimulate labor, has side effects that include nausea, vomiting and stomach pain.||Ipamorelin is a pentapeptide and a ghrelin mimetic with growth hormone releasing activity.
Ipamorelin imitates ghrelin and ties to the ghrelin receptor in the brain, thus selectively stimulating the release of growth hormone from the pituitary gland.
Growth hormones are frequently released and more abundant in children. When humans begin to age, the production of growth hormones decelerates and lessens gradually over time. The use of Ipamorelin can encourage these growth hormones to be created and released regularly.
Ipamorelin is used to help increase growth hormone production, which can assist in the reduction of body fat, enhancement of lean muscle mass, improvement of sleep, and increase of energy and over all wellness.
Ipamorelin is mostly used for collagen production, wrinkle reduction, acceleration of healing and recovery, and enhancement of mood and sleep; therefore being a peptide that is sought after for it’s anti-aging benefits.
Mechanism of Action
The function of Ipamorelin is to mimic ghrelin. The hormone ghrelin, discovered in 1999, has extreme effects on metabolism, restraining stored fat breakdown, and most importantly gherlin performs to regulate growth hormone release from the pituitary gland.
Ipamorelin fastens to ghrelin receptors on the pituitary gland, activating them identically to the way ghrelin naturally would. The activation of these receptors work collectively with no effect on the rest of the body’s hormones.
Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area.
Before administering Ipamorelin, always be sure to use a clean and sterile syringe.
Hold the Ipamorelin vial upright and insert the syringe in the center of the cap.
Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it.
Before administering the syringe, use alcohol to cleanse the area of skin.
Pinch the skin around the area to be injected, leave about 2 cm on each side.
Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe.
Depress the plunger fully, until the syringe is empty, and carefully draw out.
Dosage Amount: 100mcg - 500mcg (0.1mg to 0.5mg)
Dosage Frequency: 1-3 times daily
Recommended dose of 300mcg, 3 times daily (injection under the skin) for strength gain and performance enhancement
Recommended dose of 200mcg, 1 time daily (injection under the skin) for anti-aging purposes
For best results, it is recommended to administer Ipamorelin at the same time daily. Avoid consumption of food and liquids at least one hour before and after administering Ipamorelin.
Ipamorelin typically takes time to show results. While some patients will notice significant changes in the body after the first month, the full-benefits are usually noticed after three to six months of administering the peptide daily.
Ipamorelin is most successful with diet, exercise, consistency and time.
The most common reaction to Ipamorelin is redness and irritation around the injection site. This reaction is typically short term and normally goes away on its own.
Ipamorelin is can also increase hunger and cause dry mouth in some patients.
In less than 1% of patients that use Ipamorelin, other side effects have occurred, including: severe drowsiness, hives, vomiting, headache, nausea, difficulty swallowing, hyperactivity, chest tightness and pallor, distortion in perception of taste, and flushing of the skin.
Anti-aging: collagen production and wrinkle reduction
Increase of lean muscle mass and muscle growth
Accelerated recovery time from exercising, weight lifting and physical activity
Improvement in cellular repair and regeneration
Increase of energy, the immune system and overall wellness
Improvement in bone strength and bone mineral density composite
Higher metabolic rate and improved circulation resulting in body fat reduction
Improvement in sleep cycle, resulting in heightened mood and energy||CJC-1295 is a synthetic GHRH (growth hormone releasing hormone) analogue made up of 30 amino acids. It has been found to be highly effective with regards to the increase of growth hormone secretion and IGF-1 without negatively affecting the pulsatility of GH secretion.
CJC-1295 is often combined with Ipamorelin due to its enhanced specificity as a GHRH. This peptide generates similar increases in growth hormone secretion, but without the appetite stimulation and increase in cortisol, acetylcholine, prolactin, and aldosterone seen with other peptides in its class. This peptide has been found to be very well-tolerated and perfect when combined with Ipamorelin.
Gland Stimulated: Pituitary
Benefits of CJC-1295:
Increased growth hormone secretion and IGF-1 Levels with no increase in prolactin
Increased Body Weight and Length through increased protein synthesis
Increased Muscle Growth
Increased Bone Density
Improved Immune Function
Improved Cognition and Memory
Increased Collagen Production
Increased Fat Loss
Increased Cellular Repair and Regeneration
CJC-1295 also promotes slow wave deep sleep, which is responsible for the highest level of muscle growth and memory retention and rejuvenation
Two types of CJC 1295:
GHRH (growth hormone releasing hormone) is produced in the hypothalamus. Its pulsatile release from the hypothalamus triggers a pulsatile release of GH from the pituitary gland. GHRH has a very short half-life of only a few minutes (half-life = the time required to remove half of the substance from the blood. The shorter the half-life, the more rapidly the substance is removed from the body, and the less its effect on the body).
The first 29 amino acids of GHRH is the active segment. They are available as a manufactured peptide called Sermorelin. Sermorelin was further modified to increase its half-life to 30 minutes. This is called CJC 1295. CJC-1295 was further modified by adding DAC (Drug Affinity Complex) to it. DAC binds to a blood protein called albumin, which increases it's half-life to 8 days. It is called CJC 1295 + DAC. CJC 1295 can also be compounded in a non-DAC form which mimics a more normal physiologic GH spike each night.
The longer half-life from the DAC binding to albumin means injections are only required once or twice per week. However, the long half-life and relatively constant blood level provide a constant stimulus for GH release from the pituitary through the GHRH receptor, which is not physiological. This can decrease the GH pulse amplitude which will result in decreased GH tissue stimulation.
It is recommended when using a long-acting CJC molecule to have 'hormone holidays' of three months each three to six months, to allow the pituitary to 'recover'. During the holidays, Sermorelin is used instead of CJC 1295 + DAC.
The 'hormone holidays' may also minimize the risk of GH resistance developing. This resistance, or insensitivity, may occur via antibodies forming that bind to and inactivate GH, or by a decreased number of GH receptors on tissues (down-regulation). These are theoretical concerns as no long-term studies have been undertaken to clarify the issues.
Side effects of CJC-1295 may include injection site reactions (irritation, erythema, induration, pain, itching), headache, diarrhea, vasodilation (flushing, warmth, transient hypotension), nausea, abdominal pain.||During any physical work the body produces insulin-like growth factor. It leads to the appearance of a large number of muscle cells causing muscle growth. In addition this substance helps to accelerate the healing process. One of the types of this hormone is a peptide Peg MGF. It is similar to growth hormone because of its characteristics but the main difference is that it does not affect the ligaments and cartilage condition.
An active substance MGF has a very short half-life. To increase the effectiveness of the hormone it is possible to create a kind of capsule consisting of polyethylene glycol surrounding the hormone. The human’s body does not react to polyethylene glycol and the transit time of the hormone in the organism can be increased. With this solution Peg MGF peptide has a long lasting effect allowing you to achieve your goals.
Peg MGF feedbacks show that this peptide is especially popular among young athletes. It has been proved that the peptide has less effect on elder people so it depends on the age of the athlete. Researches show that the full course allows to increase muscle size by 15%.
The effects of Peg MGF
It is recommended to buy Peg MGF when you need to:
increase the growth of muscle tissue;
reduce the number of fat cells in the body;
increase endurance and strength;
achieve an apparent muscle relief;
accelerate the recovery of muscle cells after workout or injury;
achieve detailed venous pattern;
stimulate the formation of new venous branches.
In the addition to the above points, Peg MGF improves immune forces of the body, lowers cholesterol level in blood, strengthens the nervous system, stimulates the formation of bone marrow cells, improves skin and prevents the negative impact of the increased heart stress.
Application and dosage of Peg MGF
The peptide can be administered in two ways. In first case the dosage for Peg MGF is from 100 to 200 mcg. Preparation can be administered every 2-3 days during 5 or 6 weeks. Then the pause for 3 weeks must be made. It is recommended to inject the peptide immediately after workouts. The course is repeated if necessary until the desired result is achieved.
Side effects and contraindications
Before beginning a hormone course you must carefully read the instructions for the use of Peg MGF. In rare cases there are possible some complications such as increased growth and size of limbs and prostatic hyperplasia. So peptide administration is allowed under the careful attention of experienced professionals and after consulting a doctor.|