Ultima-Selank 5mg

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ACTIVE HALF-LIFE
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 ACNE
 WATER RETENTION
 HBR
 HEPATOTOXICITY
 AROMATIZATION

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Description

Products are shipping without brand label for security reasons.
The recent boom in biotechnology has opened the door for studying new biologically-active compounds, including “cognitive enhancers” or “nootropics.”

One such compound is Selank — previously known as “TP-7” — which belongs to a class of molecules called synthetic peptides, or small artificially-designed proteins.

Selank has been touted as an “anti-anxiety” compound, and has also been claimed to improve learning and increase energy — supposedly without side-effects or the risk of addiction.

Selank is small and only a fraction of the size of most naturally-occurring proteins. It was developed at the Institute of Molecular Genetics (Russian Academy of Sciences) in cooperation with the V.V. Zakusov Research Institute of Pharmacology (Russian Academy of Medical Sciences), along with its “cousin” drug, Semax.

Selank was derived by combining the sequence of a peptide called tuftsin with another sequence that improves its molecular stability. Tuftsin is naturally-occurring, and makes up one part of the natural antibody IgG.

Both tuftsin and Selank have been reported to reduce anxiety and increased serotonin levels in rats, with Selank being slightly more effective.

Selank has been approved in Russia for the treatment of generalized anxiety disorder (GAD) and for its use as a nootropic. However, the FDA has not approved its use for any conditions. Nonetheless, Selank continues to be available in several countries, where it is often sold as a “nutritional supplement.”

Selank Mechanism of Action

Although the mechanisms behind Selank are not yet fully known for certain, Selank is believed to act in part by stabilizing enkephalins in the blood. Enkephalins are natural peptides in the body that are believed to counteract the stress response.

However, one animal study in mice did not demonstrate the stabilization of enkephalins following dosing with Selank, and the treated mice also did not appear to benefit from any significant “anti-anxiety” effects.

According to some cell studies, Selank may bind to GABA receptors. By extensions, most compounds that bind to GABA receptors generally cause “sedative” effects. In one study of mice treated with Selank, researchers reported increased activity in inhibitory neurons, which rely on GABA. This resulted in less overall brain activity, which is generally consistent with a sedative effect.

In addition, some researchers have reported an increase in BDNF, an important brain-growth compound (neurotropic factor) which has been implicated in learning and memory. Some researchers have suggested that this mechanism may be responsible for some of Selank’s claimed cognitive effects.

Selank has also been reported to influence the levels of the neurotransmitters norepinephrine, dopamine, and serotonin in mice. These neurotransmitters are widely believed to be involved in motivation, focus, and pleasure.

However, according to one animal study in mice, Selank was reported to increase norepinephrine, but reportedly decreased dopamine and serotonin levels. In contrast, in some other treated mice, Selank was reported to increase norepinephrine and dopamine levels, and did not change serotonin. Therefore, its exact effects and mechanisms remain unclear.

Possibly Effective for:

Anxiety

According to one preliminary clinical trial on 62 people, those given Selank reported fewer anxiety symptoms, with a greater decrease being observed in those suffering from pre-existing anxiety disorders.

In another trial, similar benefits were reported in 60 patients suffering from anxiety and phobias, with these effects lasting up to a week after the final dose.

Additionally, in one study of 70 anxiety patients, Selank was reported to increase the effects of phenazepam (an anti-anxiety drug banned in some U.S. states for its recreational use), while also reportedly reducing its rates of negative side-effects (such as drowsiness and memory loss).

In one animal study, Selank was reported to reduce anxiety in mice. The more anxious the mice were to begin with, the more significant the observed changes in their behavior after treatment.

Additionally, Selank was reported to show “anti-anxiety” effects in one study of rats who received 4 weeks of daily treatment.

Although limited, some of the above evidence suggests that Selank may potentially help curb anxiety, although much more research will still be needed to confirm its effectiveness and safety in human users. If you suffer from anxiety, you could have a discussion with your doctor about whether taking Selank might help you — however, always remember that you should never take this supplement in place of what your doctor recommends or prescribes.

Memory

Selank was reported to stabilize memory traces (i.e. potentially improve memory storage) in rats during one 30-day trial. However, it is unclear how these measurements were performed, as memory traces are not detectable as discrete locations in the brain.

One other animal study has reported that Selank may also preserve memory in monkeys.

However, appropriate human studies are lacking, and remains unknown what effects — if any — Selank might have in healthy human users. It is also unclear whether or not this compound would be safe for such users to take (either in the short- or long-term), and so caution would be advised until much more additional research is performed.

Brain Damage Recovery

In one study, researchers gave Selank supplements to rats with toxin-induced brain damage. This drug reportedly restored their brain activity to normal levels.

Depression

Selank has been reported to decrease depression symptoms (immobility during a forced swimming test) in mice. Curiously, it was reported to be more effective at relatively lower rather than higher doses.

Antioxidant Activity in the Liver

In one preliminary animal study, injection of Selank was reported to increase the levels of antioxidants in the livers of stressed mice.

Blood Flow

In one animal study of sedated cats, Selank was reported to decrease blood pressure by about 30% for up to 3 minutes.

It also increased blood flow to the cats’ brain by about 24% for up to 10 minutes [30].

While these preliminary findings are interesting in that they suggest that Selank may have some short-term cardiovascular effects on blood flow, the relatively short durations of these effects is hard to interpret, and may suggest that these effects are not strong or medically significant.

Additionally, these were only observed in animals, and so whether these effects would be similar in healthy human users remains unclear.

Alcohol Withdrawal

Anxiety is one of the more common symptoms involved in alcohol withdrawal. To mimic high alcohol intake, rats were given a 10% solution of ethanol (alcohol) as their sole drinking source for 24 weeks. Selank reportedly decreased the anxiety of these rats after a 48-hour alcohol withdrawal period.

Preventing Weight Gain and Reducing Cholesterol

According to one animal study, rats who were fed a high-fat diet reportedly showed 35% less weight gain when treated with Selank. Additionally, total cholesterol levels for these rats were reportedly reduced by over 58%, and blood glucose levels were reduced by 23.5%.

Cancer

In one animal study, mice with breast cancer were treated with daily doses of Selank and had slower tumor growth. Also, these mice reportedly lived longer than their untreated counterparts.

However, this preliminary finding doesn’t mean that Selank has any value in anticancer therapy. Much more research would be needed to verify and extend these early findings into legitimate medical treatments for cancer. Do not under any circumstances attempt to replace conventional cancer therapies with Selank (or any other supplements)!

Inflammation in the Spleen

After treatment with Selank, the spleens of mice were reported to show increased levels of several inflammatory response genes, which may suggest some degree of protection against the harmful effects of inflammation.

Ulcers

Selank has been reported to reduce the size (area) of stomach ulcers in animal models.

Some researchers have speculated that this may be because this drug increases the flow of lymph — an important component of the immune system — to the stomach.

Nonetheless, much more research in humans would be needed to confirm this effect, as well as its potential mechanisms.

Immune Function

Selank reportedly increased IL-6 in blood cells collected from patients suffering from depression. IL-6 is an inflammatory protein that is believed to help fight off infections.

Additionally, according to one cell-based study, Selank was reported to stimulate the release of interferons, which are anti-viral molecules.

Selank has also been proposed to potentially protect cells against some viral infections. However, one animal study in mice infected with a virus did not report any anti-viral benefits from Selank treatment, which casts doubt on this potential use.

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DescriptionACTIVE HALF-LIFE  CLASSIFICATION  DOSAGE  ACNE  WATER RETENTION  HBR  HEPATOTOXICITY  AROMATIZATIONACTIVE HALF-LIFE  CLASSIFICATION Glycoprotein hormones, alpha polypeptide  DOSAGE 500-3000IU 1-3 times/week  ACNE Possible  WATER RETENTION No  HBR No  HEPATOTOXICITY No  AROMATIZATION NoACTIVE HALF-LIFE 16 days  CLASSIFICATION Anabolic Steroid  DOSAGE 500-700 mg/week  ACNE Yes  WATER RETENTION No  HBR No  HEPATOTOXICITY Low  AROMATIZATION MediumACTIVE HALF-LIFE 7-9 days  CLASSIFICATION Anabolic Steroid  DOSAGE 400-1200 mg/week  ACNE Yes  WATER RETENTION Yes  HBR Perhaps  HEPATOTOXICITY No  AROMATIZATION YesACTIVE HALF-LIFE 5-7 Days  CLASSIFICATION Anabolic Steroid  DOSAGE Men 200-600 mg/week  ACNE Rarely  WATER RETENTION Yes  HBR Perhaps  HEPATOTOXICITY Yes  AROMATIZATION NoACTIVE HALF-LIFE  CLASSIFICATION Peptide Hormone  DOSAGE  ACNE No  WATER RETENTION No  HBR No  HEPATOTOXICITY No  AROMATIZATION No
ContentProducts are shipping without brand label for security reasons. The recent boom in biotechnology has opened the door for studying new biologically-active compounds, including “cognitive enhancers” or “nootropics.” One such compound is Selank — previously known as “TP-7” — which belongs to a class of molecules called synthetic peptides, or small artificially-designed proteins. Selank has been touted as an “anti-anxiety” compound, and has also been claimed to improve learning and increase energy — supposedly without side-effects or the risk of addiction. Selank is small and only a fraction of the size of most naturally-occurring proteins. It was developed at the Institute of Molecular Genetics (Russian Academy of Sciences) in cooperation with the V.V. Zakusov Research Institute of Pharmacology (Russian Academy of Medical Sciences), along with its “cousin” drug, Semax. Selank was derived by combining the sequence of a peptide called tuftsin with another sequence that improves its molecular stability. Tuftsin is naturally-occurring, and makes up one part of the natural antibody IgG. Both tuftsin and Selank have been reported to reduce anxiety and increased serotonin levels in rats, with Selank being slightly more effective. Selank has been approved in Russia for the treatment of generalized anxiety disorder (GAD) and for its use as a nootropic. However, the FDA has not approved its use for any conditions. Nonetheless, Selank continues to be available in several countries, where it is often sold as a “nutritional supplement.” Selank Mechanism of Action Although the mechanisms behind Selank are not yet fully known for certain, Selank is believed to act in part by stabilizing enkephalins in the blood. Enkephalins are natural peptides in the body that are believed to counteract the stress response. However, one animal study in mice did not demonstrate the stabilization of enkephalins following dosing with Selank, and the treated mice also did not appear to benefit from any significant “anti-anxiety” effects. According to some cell studies, Selank may bind to GABA receptors. By extensions, most compounds that bind to GABA receptors generally cause “sedative” effects. In one study of mice treated with Selank, researchers reported increased activity in inhibitory neurons, which rely on GABA. This resulted in less overall brain activity, which is generally consistent with a sedative effect. In addition, some researchers have reported an increase in BDNF, an important brain-growth compound (neurotropic factor) which has been implicated in learning and memory. Some researchers have suggested that this mechanism may be responsible for some of Selank’s claimed cognitive effects. Selank has also been reported to influence the levels of the neurotransmitters norepinephrine, dopamine, and serotonin in mice. These neurotransmitters are widely believed to be involved in motivation, focus, and pleasure. However, according to one animal study in mice, Selank was reported to increase norepinephrine, but reportedly decreased dopamine and serotonin levels. In contrast, in some other treated mice, Selank was reported to increase norepinephrine and dopamine levels, and did not change serotonin. Therefore, its exact effects and mechanisms remain unclear. Possibly Effective for: Anxiety According to one preliminary clinical trial on 62 people, those given Selank reported fewer anxiety symptoms, with a greater decrease being observed in those suffering from pre-existing anxiety disorders. In another trial, similar benefits were reported in 60 patients suffering from anxiety and phobias, with these effects lasting up to a week after the final dose. Additionally, in one study of 70 anxiety patients, Selank was reported to increase the effects of phenazepam (an anti-anxiety drug banned in some U.S. states for its recreational use), while also reportedly reducing its rates of negative side-effects (such as drowsiness and memory loss). In one animal study, Selank was reported to reduce anxiety in mice. The more anxious the mice were to begin with, the more significant the observed changes in their behavior after treatment. Additionally, Selank was reported to show “anti-anxiety” effects in one study of rats who received 4 weeks of daily treatment. Although limited, some of the above evidence suggests that Selank may potentially help curb anxiety, although much more research will still be needed to confirm its effectiveness and safety in human users. If you suffer from anxiety, you could have a discussion with your doctor about whether taking Selank might help you — however, always remember that you should never take this supplement in place of what your doctor recommends or prescribes. Memory Selank was reported to stabilize memory traces (i.e. potentially improve memory storage) in rats during one 30-day trial. However, it is unclear how these measurements were performed, as memory traces are not detectable as discrete locations in the brain. One other animal study has reported that Selank may also preserve memory in monkeys. However, appropriate human studies are lacking, and remains unknown what effects — if any — Selank might have in healthy human users. It is also unclear whether or not this compound would be safe for such users to take (either in the short- or long-term), and so caution would be advised until much more additional research is performed. Brain Damage Recovery In one study, researchers gave Selank supplements to rats with toxin-induced brain damage. This drug reportedly restored their brain activity to normal levels. Depression Selank has been reported to decrease depression symptoms (immobility during a forced swimming test) in mice. Curiously, it was reported to be more effective at relatively lower rather than higher doses. Antioxidant Activity in the Liver In one preliminary animal study, injection of Selank was reported to increase the levels of antioxidants in the livers of stressed mice. Blood Flow In one animal study of sedated cats, Selank was reported to decrease blood pressure by about 30% for up to 3 minutes. It also increased blood flow to the cats’ brain by about 24% for up to 10 minutes [30]. While these preliminary findings are interesting in that they suggest that Selank may have some short-term cardiovascular effects on blood flow, the relatively short durations of these effects is hard to interpret, and may suggest that these effects are not strong or medically significant. Additionally, these were only observed in animals, and so whether these effects would be similar in healthy human users remains unclear. Alcohol Withdrawal Anxiety is one of the more common symptoms involved in alcohol withdrawal. To mimic high alcohol intake, rats were given a 10% solution of ethanol (alcohol) as their sole drinking source for 24 weeks. Selank reportedly decreased the anxiety of these rats after a 48-hour alcohol withdrawal period. Preventing Weight Gain and Reducing Cholesterol According to one animal study, rats who were fed a high-fat diet reportedly showed 35% less weight gain when treated with Selank. Additionally, total cholesterol levels for these rats were reportedly reduced by over 58%, and blood glucose levels were reduced by 23.5%. Cancer In one animal study, mice with breast cancer were treated with daily doses of Selank and had slower tumor growth. Also, these mice reportedly lived longer than their untreated counterparts. However, this preliminary finding doesn’t mean that Selank has any value in anticancer therapy. Much more research would be needed to verify and extend these early findings into legitimate medical treatments for cancer. Do not under any circumstances attempt to replace conventional cancer therapies with Selank (or any other supplements)! Inflammation in the Spleen After treatment with Selank, the spleens of mice were reported to show increased levels of several inflammatory response genes, which may suggest some degree of protection against the harmful effects of inflammation. Ulcers Selank has been reported to reduce the size (area) of stomach ulcers in animal models. Some researchers have speculated that this may be because this drug increases the flow of lymph — an important component of the immune system — to the stomach. Nonetheless, much more research in humans would be needed to confirm this effect, as well as its potential mechanisms. Immune Function Selank reportedly increased IL-6 in blood cells collected from patients suffering from depression. IL-6 is an inflammatory protein that is believed to help fight off infections. Additionally, according to one cell-based study, Selank was reported to stimulate the release of interferons, which are anti-viral molecules. Selank has also been proposed to potentially protect cells against some viral infections. However, one animal study in mice infected with a virus did not report any anti-viral benefits from Selank treatment, which casts doubt on this potential use.Eurigil (HCG) 5000IU is an injectable drug manufactured by Euro-Pharmacies and containing as active substance Human Chorionic Gonadotropin (hCG). This is a hormone produced during pregnancy that is made by the developing placenta after conception, and later by the placental component syncytiotrophoblast. One of the uses of hCG is to suppress hunger and trigger the human body’s use of fat for fuel. hCG is used also to cause ovulation and to treat infertility in women, and to increase sperm count in men. bodybuilders use it in steroids cycles and in post cycle therapy to lose gain and to increase Testosterone production. Eurigil (HCG) 5000IU is utilized among bodybuilders and athletes at the end of an anabolic-androgenic steroid cycle to prevent the breakdown of muscle tissue. It is also important in restoring the testes to the normal abilities. Many times after a period of anabolic steroids usage the testes of an athlete may shrink. Pregnyl is effective in returning them to normal size. When used along with a very low-calorie diet, athletes burn off that extra fat over their muscle mass. Females may also use Pregnyl with a very low calorie diet to burn off unnecessary fat. The average dosage of Eurigil (HCG) 5000IU during a cycle is between 500iu to 3000iu every week (1-3 times per week). If the injection is taken more frequently the blood level of the athlete are more stable while taking it in one shot may increase the estrogen levels caused by the aromatization of normal Testosterone and result in gynecomastia. There are sources showing that some bodybuilders used 6000iu for 6 days, but this is a risky affair and depend on the individual features of men. As post cycle therapy Pregnyl should be used in smaller doses, about 250 – 500iu every day for 2 or 3 weeks. Smaller doses are enough to begin reversal process of testicular atrophy. When starting a cycle of hCG, bodybuilders must follow it for 2 to 3 week range with a least one month off in between and follow this course with no concern. Pregnyl can be used with Clomid or Nolvadex in the PCT and continue using them after HCG is no longer part of the cycle. It is also recommended to start and hCG cycle near the end of a normal steroids cycle, most effective in the last week. The most serious side effects that may occur while using Eurigil (HCG) 5000IU are: severe pelvic pain, swelling of the hands or legs, stomach pain and swelling, shortness of breath, weight gain, diarrhea, nausea or vomiting. Other common side effects of Pregnyl are: headache, feeling restless or irritable, mild swelling or water weight gain, depression, breast tenderness or swelling; or pain, swelling, or irritation where the injection is given. Among boys the medicine can cause early signs of puberty, such as a deepened voice, pubic hair growth, and increased acne or sweating.Trenbolone Enanthate – injectable steroid that is used mainly in bodybuilding and weightlifting to achieve maximum growth of compacted muscle mass and a significant increase in power capacity. Trenbolone Enanthate ester is characterized by a long period of exposure into the body (about six weeks). Trenbolone Enanthate Effects significant increase in muscle mass (average 10 kg per 8 weeks); increasing the degree of endurance and power performance; 200% increase in the level of insulin-like growth factor stimulation and hyperplasia of the muscle; fat burning effect (including the influence due to the release of growth hormone); lowering cortisol levels (a hormone which facilitates the destruction of proteins, increased fat accumulation and glucose). How to Use Trenbolone Enanthate: Dosage, Cycle, PCT To create a cycle for Trenbolone Enanthate, which also would be effective and safe for the body, stick to a few rules: Do not exceed the dosage of the drug and duration of the cycle (the optimal dose of Trenbolone Enanthate per week – 300 mg, cycle length – 6-8 weeks). Always start with a minimum rate of injection to fix the body’s response to anabolic effects. Take Gonadotropins, if the steroid cycle is designed for 5 weeks and more. Do not neglect the power of sports complex and a special diet for weight gain. Always consult a doctor before starting the cycle. Trenbolone Enanthate Combination Cycles Trenbolone Enanthate, to gain muscle mass, is often taken solo, because of its efficiency. In professional cycles at a dosage of 250 mg per week, can be stacked with Testosterone Enanthate, but this combination is only valid for the experienced athletes, and after a medical advice. For drying period one can buy Winstrol, or Anavar without anti-estrogens, using half of the dosage. As PCT on Trenbolone cycle is used Toremifene or Clomid. Trenbolone Enanthate Reviews After analyzing published on Trenbolone Enanthate reviews, it is easy to draw a conclusion about the quality of weight and severity of the effect: more than 90% of athletes and bodybuilders were satisfied with the results of the cycle. The absence of the phenomenon of rollback and flavoring also played a significant role in relation of athletes with this steroid. Warnings: Keep out of reach of children. For adults only.Insulin-like growth factor-1 (IGF-1) helps encourage normal bone and tissue growth and development and also has the ability to decrease blood glucose levels. IGF-1 advances to fat cells and therefore burns fat. Subsequently, it increases lean body mass and decreases fat. These effects are desired mostly by athletes and bodybuilders. Increased IGF-1 levels are also comparable to weight gain. This weight gain is a result of lean body mass growth, not fat production. IGF-1 is favored in the bodybuilding industry and for people who workout regularly. It helps enhance recovery time after workout and improves energy during the workout. IGF-1 injections are common for adults and children if they have a growth hormone deficiency. IGF-1 contains many necessary amino acids that can help children who are not developing at a standard rate and supplement adults that are deficient. Research has also shown that the anabolic effects of IGF-1 may reflect inhibited protein breakdown and stimulated protein synthesis in skeletal muscle and that this response may be caused by a direct effect of IGF-1 on muscle tissue, therefore assisting burns on the skin and other tissue abnormalities. Mechanism of Action IGF-1 is a hormone found naturally in human blood. Its primary function is to manage the effects of growth hormone in the body. Normal IGF-1 and growth hormone functions include tissue and bone growth. IGF-1 is formed in different tissues as a result of growth hormone in the blood. IGF-1 promotes systemic body growth, and has growth-stimulating effects on mostly every cell in the body, mainly bone, cartilage, skeletal muscle, liver, kidney, nerve, skin and lung cells. As well as the insulin-like effects, IGF-1 can also manage cellular DNA synthesis. Administration Mode of Administration: Subcutaneous injection to a fleshy part of the body, typically to the stomach or abdominal area. IGF-1 can also be administered intramuscularly. Before administering IGF-1, always be sure to use a clean and sterile syringe. Hold the IGF-1 vial upright and insert the syringe in the center of the cap. Draw the plunger until you have the correct amount (see ‘Dosage’ below) in the syringe and carefully remove it. Before administering the syringe, use alcohol to cleanse the area of skin. Pinch the skin around the area to be injected, leave about 2 cm on each side. Hold the syringe at a 90 degree angle to your skin and swiftly insert the syringe. Depress the plunger fully, until the syringe is empty, and carefully draw out. Dosage Dosage Amount: For lean muscle growth and fat loss 40 mcg - 50 mcg daily (men) 10 mcg - 20 mcg daily (women) IGF-1 should not be injected more than twice daily A typical dosage cycle of IGF-1 will continue for 2 to 12 weeks Children and adults who are prescribed IGF-1 for development deficiency should consult with a care provider about correct dosing. Side Effects The side effects of IGF-1 can be similar to those of other growth hormones. These include growth of excess body tissue, also known as acromegaly, and damage to the joints, liver, and heart. IGF-1 could possibly cause joint pain, muscle pain, headaches and nausea. IGF-1 can also decrease levels of blood glucose, resulting in hypoglycemia. Researchers also associate IGF-1 with an increased risk of developing some cancers, such as lung, breast, colorectal and prostate. Benefits Facilitation of protein synthesis in the body Regulation of stored fat and channeling it to be used for energy production, resulting in fat loss Promotion of positive effects on metabolism and increasing lean body mass and muscle growth Protection against autoimmune disease, heart disease and plaque buildup Aid development in young children and adults deficient in essential amino acids Improvement in blood sugar regulation Promotion of optimal health, wellness and fitness in users
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